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Ginseng extract reference substance as well as preparation method and application thereof

A technology of ginseng extraction and reference substances, applied in the field of chemistry, can solve the problems of high detection cost and incomplete detection standards

Pending Publication Date: 2019-10-25
广州万正药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above-mentioned technical problems, the present invention has incomplete detection standards in the detection of ginseng preparations or ginseng medicinal materials, and the problem of high detection cost by using multiple reference substances. Ginseng extract reference substance for simultaneous detection of compounds in

Method used

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  • Ginseng extract reference substance as well as preparation method and application thereof
  • Ginseng extract reference substance as well as preparation method and application thereof
  • Ginseng extract reference substance as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] Take ginseng medicinal materials and add 70% ethanol to reflux or flash extraction, extract 60 minutes each time, extract 3 times, combine the filtrates, concentrate, add an appropriate amount of alumina to mix the sample, make a powder sample, pass through the alumina chromatography column, Elute with 50% ethanol aqueous solution, collect the eluate, evaporate to dryness, dissolve the residue in water, pass through a polystyrene chromatography column to elute with water and 95% ethanol respectively, collect the 95% ethanol eluate, concentrate and dry to obtain the final product.

Embodiment 2

[0180] Take ginseng and add 70% ethanol to flash extraction, extract 2 minutes each time, extract 3 times, combine the filtrates, concentrate, add an appropriate amount of alumina to mix the sample, make a powder sample, pass through the alumina chromatography column, use 90 Elute with % ethanol aqueous solution, collect the eluate, evaporate to dryness, dissolve the residue in water, and elute with water and 95% ethanol respectively through a polystyrene chromatography column, collect the 95% ethanol eluate, concentrate and dry to obtain the final product.

Embodiment 3

[0182] Take ginseng and add 90% ethanol to reflux or flash extraction, extract twice for 120 minutes each time, combine the filtrates, concentrate, add an appropriate amount of alumina to mix the sample, make a powder sample, pass through the alumina chromatography column, Elute with 70% ethanol aqueous solution, collect the eluate, evaporate to dryness, dissolve the residue in water, pass through a polystyrene chromatography column to elute with water and 95% ethanol respectively, collect the 95% ethanol eluate, concentrate and dry.

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Abstract

The invention provides a ginseng extract reference substance for simultaneously detecting compounds in a ginseng medicinal material, a ginseng extract and a ginseng preparation and a preparation method thereof. The ginseng extract reference substance is white-yellow dry powder, wherein the content of total saponins of panax ginseng is not less than 50 percent; and the total content of ginsenosideRb1, ginsenoside Re and ginsenoside Rg1 is not less than 20 percent. The ginseng extract reference substance can be applied to quality control of ginseng medicinal materials and ginseng prescriptionsand qualitative and quantitative analysis and determination of effective compounds.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a ginseng extract reference substance and its application. Background technique [0002] Drug inspection is an important means to verify the quality of drugs. With the widespread use of instrumental analysis, more and more drug reference materials are used. In drug inspection work, reference substances are often used as a special reference for checking the quality of drugs, and as a comparison standard for determining the authenticity of drugs. Reference substances play a very important role in drug testing. [0003] In the current standard of traditional Chinese medicine, the quality control mode of a single component is difficult to reflect the quality of traditional Chinese medicine, and the method of comprehensive quality control using multiple components or characteristic chromatographic peaks has attracted more and more attention. However, the shortage of commercial r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/90
CPCG01N30/02G01N30/06G01N30/90
Inventor 许舜军郭隆钢许艺镌
Owner 广州万正药业有限公司
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