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Application of lncRNA TRAM2 as a glaucoma diagnostic marker

A technology for glaucoma and angle-closure glaucoma, applied in DNA/RNA fragments, recombinant DNA technology, microbial measurement/testing, etc., to achieve far-reaching clinical significance and promotional effects

Active Publication Date: 2020-05-26
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, clinical treatment mainly focuses on lowering intraocular pressure and neuroprotection, but about 10% of patients are blind eventually, and the inability to effectively control the progressive apoptosis of retinal ganglion cells (RGCs) and promote post-injury repair and regeneration is the bottleneck.

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  • Application of lncRNA TRAM2 as a glaucoma diagnostic marker
  • Application of lncRNA TRAM2 as a glaucoma diagnostic marker
  • Application of lncRNA TRAM2 as a glaucoma diagnostic marker

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Embodiment Construction

[0023] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, without limiting the present invention.

[0024] 1.1 Preparation of experimental group specimens:

[0025] The blood samples of 186 patients were collected from outpatients or inpatients of the Eye Hospital Affiliated to Wenzhou Medical University from April 2017 to March 2018, including 62 cases of primary open-angle glaucoma, primary angle-closure glaucoma 124 cases. During the same period, 60 cases of simple cataract control group were collected, and those with systemic diseases, other eye diseases and surgery were excluded from the subjects. Exclude patients with chronic diseases such as diabetes and hypertension, and patients with systemic diseases such as infection; exclude patients with other eye diseases or surgery history. The situation of the cases is shown in Table 1. The abbreviations that appear below represent respectively: PACG...

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Abstract

The invention discloses a marker lncRNA for early diagnosis of glaucoma, the marker is lncRNA TRAM2, and research shows that the lncRNA TRAM2 has up-regulated expression in plasma and plasma exosomesof a patient with primary glaucoma. The invention provides application of a product for detecting the expression level of the lncRNA TRAM2 to preparation of glaucoma disease diagnosis tools.

Description

technical field [0001] The invention relates to the technical field of molecular diagnosis, in particular to the application of lncRNA TRAM2 in preparing glaucoma disease diagnostic tools. Background technique [0002] Vision is the most important sense of humans and animals, and at least 80% of the external information is obtained through vision. Glaucoma is the second blinding eye disease and the first irreversible blinding eye disease in the world. It is a neurodegenerative disease that causes optic nerve atrophy, visual field defect, and eventually blindness due to various reasons such as pathological high intraocular pressure. At present, clinical treatment mainly focuses on lowering intraocular pressure and neuroprotection, but about 10% of patients are blind eventually. The bottleneck lies in the failure to effectively control the progressive apoptosis of retinal ganglion cells (RGCs) and promote the repair and regeneration after injury. Glaucoma means the beginning ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/113
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 池在龙张文梦
Owner WENZHOU MEDICAL UNIV