Traditional Chinese medicine composition for alleviating hypotension related to hemodialysis

A technology of hemodialysis and correlation, applied in the field of traditional Chinese medicine, can solve problems such as abnormal function of vascular endothelial cells, increase heart rate and myocardial oxygen consumption, and affect water clearance in hemodialysis patients, so as to increase capacity burden, reduce incidence, The effect of reducing the number of dialysis interruptions

Inactive Publication Date: 2019-11-19
SHANGHAI SEVENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Disadvantages: Western medicine: Long-term use of hypertonic sugar water will lead to abnormal function of vascular endothelial cells, increase heart rate and myocardial oxygen consumption, and seriously affect cardiovascular function, while infusion of normal saline or adjustment of dialysis prescription will affect the removal of water in hemodialysis patients , resulting in inadequate hemodialysis
Traditional Chinese Medicine: Single herbs and small prescriptions are not effective in improving IDH, and Chinese medicine intravenous preparations have the disadvantages of impure preparations and easy allergies
The effect of western medicine treatment is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The traditional Chinese medicine composition for improving hemodialysis-associated hypotension of this embodiment is composed of the following raw materials in parts by weight: 30 parts of raw astragalus, 15 parts of aconite, 6 parts of cinnamon, 9 parts of Cimicifuga, 9 parts of Polygonatum polygonatum, and 6 parts of Asarum 9 parts of Ephedra, 9 parts of Guizhi, 9 parts of Chuanwu, 9 parts of Caowu, 15 parts of Epimedium, 9 parts of red ginseng and 6 parts of Zhigancao.

[0031] Grind each raw material in the Chinese medicine composition into fine powder, pass through a 120-mesh sieve, and dry at a temperature of 100°C for 20-30 minutes to obtain a Chinese medicine composition powder, and prepare the Chinese medicine composition powder with vaseline ointment, the mass ratio of the powder of the traditional Chinese medicine composition to petrolatum is 1:1.

[0032] Zhang, 49 years old, male, suffers from chronic renal insufficiency, chronic nephritis, and renal anemia...

Embodiment 2

[0035] The traditional Chinese medicine composition for improving hemodialysis-associated hypotension of this embodiment is composed of the following raw materials in parts by weight: 27 parts of raw astragalus, 17 parts of aconite, 5 parts of cinnamon, 9.5 parts of Cimicifuga, 8 parts of Polygonatum Polygonatum, and 7 parts of Asarum 10 parts of Ephedra, 10 parts of Guizhi, 11 parts of Chuanwu, 10 parts of Aconitum, 17 parts of Epimedium, 11 parts of red ginseng and 7 parts of Zhigancao.

[0036] Using the method of Example 1, the powder of the Chinese medicine composition of the present example was prepared into a Chinese medicine composition ointment with petroleum jelly, and performed umbilical cord therapy.

[0037] Wang, 37 years old, male, suffers from uremia. He went to the doctor because of "nausea and vomiting for two days". The blood creatinine was 896.4 μmol / L. The weight increased by 4-5kg during the interval, the blood pressure was about 160 / 80mmHg before dialysi...

Embodiment 3

[0040] The traditional Chinese medicine composition for improving hemodialysis-associated hypotension of this embodiment is composed of the following raw materials in parts by weight: 33 parts of raw astragalus, 14 parts of aconite, 7 parts of cinnamon, 8.5 parts of Cimicifuga, 11 parts of Polygonatum Polygonatum, 6.5 parts of Asarum 11 parts of Ephedra, 11 parts of Guizhi, 7 parts of Chuanwu, 8.5 parts of Aconiti, 13 parts of Epimedium, 10 parts of red ginseng and 5 parts of Zhigancao.

[0041] By the method of Example 1, the powder of the Chinese medicine composition of the present embodiment is prepared into a Chinese medicine composition ointment with vaseline.

[0042] Chen, 57 years old, female, suffered from uremia, hypertensive nephropathy, grade 3 hypertension, renal anemia, and renal bone disease. "Two years in high school" went to the doctor, usually a small amount of foamy urine, nocturia 3-5 times / day, serum creatinine gradually increased to 752μmol / L, and hemodia...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for alleviating hypotension related to hemodialysis. The traditional Chinese medicine composition consists of unprocessed astragalus membranaceus, aconitum carmichaeli root pieces, cinnamon, rhizoma cimicifugae, polygonatum odoratum, asarum, herba ephedra, cassia twigs, monkshood, radix aconiti kusnezoffii, herba epimedii, red ginseng and honey-fried licorice roots. According to the traditional Chinese medicine composition, unprocessed astragalus membranaceus, red ginseng, aconitum carmichaeli root pieces, cinnamon and cassia twigs are adopted for tonifying qi and warming yang, rhizoma cimicifugae, herba ephedra and asarum are adopted for boosting yang and ascending deficiency as well as stimulating yang qi, monkshood, radixaconiti kusnezoffii and herba epimedii are adopted for warming yang and expelling coldness, polygonatum odoratum is capable of nourishing yin and seeking yang from yin, licorice roots are capable ofharmonizing the medicines, and with the combination of the medicines, effects of tonifying qi and warming yang as well as recovering yang and ascending deficiency can be taken into play, and an effectof treating root causes can be achieved; the traditional Chinese medicine composition for alleviating hypotension related to hemodialysis, which is provided by the invention, is remarkable in treatment effect, the occurrence rate of hypotension related to hemodialysis can be remarkably reduced, the interruption times of hemodialysis can be reduced, the interference times of medical operators canbe reduced, the cost is low, the security is high, and the capacity burden of patients is not increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for improving hemodialysis-associated hypotension. Background technique [0002] Hemodialysis-related hypotension (IDH) refers to patients with systolic blood pressure (SBP) decreased by more than 20mmHg or mean arterial pressure decreased by more than 10mmHg during dialysis, accompanied by symptoms of hypotension. Epidemiological surveys show that the incidence of hemodialysis-associated hypotension is about 30%, so it is the most important acute complication in hemodialysis. Traditional Chinese medicine believes that IDH belongs to the category of "dizziness" and "jueni". When IDH occurs, patients may manifest as dizziness, cold sweats, yawning, warm hands and feet or desire to defecate, and in severe cases, they may manifest as pale complexion, nausea and vomiting. , abdominal pain, low back pain, che...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P9/02A61P7/08
CPCA61K36/17A61K36/258A61K36/268A61K36/296A61K36/481A61K36/484A61K36/54A61K36/71A61K36/714A61K36/8969A61P7/08A61P9/02A61K2300/00
Inventor 陈晛路建饶廖琳
Owner SHANGHAI SEVENTH PEOPLES HOSPITAL
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