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A small artificial bionic blood vessel perfusion fluid pressure testing system and method

A bionic blood vessel and fluid pressure technology, applied in the direction of applying stable tension/pressure to test the strength of materials, measuring devices, instruments, etc., to achieve the effect of small size and simple operation process

Active Publication Date: 2021-02-19
XI AN JIAOTONG UNIV
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Problems solved by technology

[0003] In order to solve the test problem of artificial bionic blood vessel perfusion pressure in the above-mentioned laboratory, the present invention provides a small artificial bionic blood vessel perfusion fluid pressure testing system and method

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  • A small artificial bionic blood vessel perfusion fluid pressure testing system and method
  • A small artificial bionic blood vessel perfusion fluid pressure testing system and method

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Embodiment Construction

[0024] The present invention will be further described in detail below in conjunction with the accompanying drawings.

[0025] Such as figure 1 with figure 2 As shown, a small artificial bionic blood vessel fluid pressure testing system provided by the present invention includes a liquid storage bottle 1 , a self-priming pump 2 , a perfusion bioreactor 8 and an artificial bionic blood vessel 9 to be tested.

[0026] figure 2 Among them, the artificial bionic blood vessel 9 to be tested uses the prepared medium-viscosity sodium alginate solution and calcium chloride solution, and is extruded through a syringe pump and a coaxial nozzle, and the two solutions undergo a cross-linking reaction to form a hollow gel tube structure. Among them, the hemolytic concentration of sodium alginate is 2%-4% (w / v), the concentration of calcium chloride solution is 4% (w / v), the flow rate of the syringe pump is 1ml / min and 1.5ml / ml respectively, and the coaxial nozzle is 19G / 26G, the nozzl...

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Abstract

The invention discloses a small artificial bionic blood vessel perfusion fluid pressure testing system and method. The testing system comprises a liquid storage tank, a perfusion bioreactor and the like, a tested artificial bionic blood vessel is arranged in the perfusion bioreactor, and two ends of the tested artificial bionic blood vessel are respectively connected with Luer taper through metaldispensing needles; a water suction port of a self-priming pump communicates with a liquid storage bottle, a water outlet of the self-priming pump is divided into two paths through a first ball valve,one path communicates with the liquid storage tank through a first pressure transmitter, the other path communicates with the Luer taper at one end of the tested artificial bionic blood vessel through a second ball valve, and the Luer taper at the other end of the tested artificial bionic blood vessel communicates with the liquid storage tank through a second pressure transmitter and a third ballvalve. According to the testing method, liquid pressure is set for the testing system to serve as a testing pressure, the tested artificial bionic blood vessel is connected into the system, it is tested whether the artificial bionic blood vessel can be kept complete or not under the set pressure, the phenomena of damage, leakage and the like, the testing system is small in size, and the testing method and operation are simple.

Description

technical field [0001] The invention belongs to the intersecting fields of mechanical automation, biotechnology and tissue engineering, and specifically relates to a small artificial bionic blood vessel perfusion fluid pressure testing system and method. Background technique [0002] With the development of biomanufacturing and tissue engineering, artificial implants are expected to be used in the replacement and repair of human tissues. As one of the important parameters clinically used to monitor the vital signs of the human body, blood pressure is often used to evaluate the physical condition of the patient. With the development of biomanufacturing technology and tissue engineering technology, 3D bioprinting of artificial hollow bionic blood vessels is expected to be applied clinically, and the replacement of blood vessels in patients can be realized through transplantation. Therefore, it is necessary to test the tolerable fluid pressure in the artificial bionic blood ve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N3/12G01N3/02
CPCG01N3/02G01N3/12
Inventor 连芩赵廷泽李涤尘呼延一格焦天高琳何晓宁官浩
Owner XI AN JIAOTONG UNIV
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