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Polygonatum sibiricum steroid sapogenin and preparation method and application thereof

A technology of steroidal saponin and steroidal saponin, which is applied in the field of development and utilization of traditional Chinese medicine, and can solve problems such as side effects

Pending Publication Date: 2019-11-29
江西省药品检验检测研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is traditionally believed that if Polygonatum is not processed or processed unreasonably, it may cause some side effects, and Rhizoma Polygonatum should not be used in clinical practice, but Rhizoma Polygonatum should be used

Method used

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  • Polygonatum sibiricum steroid sapogenin and preparation method and application thereof
  • Polygonatum sibiricum steroid sapogenin and preparation method and application thereof
  • Polygonatum sibiricum steroid sapogenin and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of Polygonatum Steroidal Saponins in Stewed Polygonatum in Embodiment 1

[0040] 1. Source of medicinal materials and preparation of stewed sealwort

[0041] Polygonatum polyflora medicinal material used in the present invention is the dry rhizome of Polygonatum polyflora of Liliaceae plant, which is purchased from the medicinal material market in Zhangshu City, Jiangxi Province, and identified by Professor Fu Xiaomei, School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, and the preserved specimens are used for drug inspection and testing research in Jiangxi Province Hospital Herbarium of Traditional Chinese Medicine.

[0042] Stewed Rhizoma Polygonatum: Take the pure Rhizoma Polygonatum, rinse it with clean water for one day, take it out, drain it, put it in the pot of stewed medicine and stew it for 24 hours, until the medicine is cooked through, take it out, dry it at 50°C, add 20% rice wine to spray evenly, and moisten it , when the w...

Embodiment 3

[0071] Example 3 Protection Experiment of Polygonatum Steroidal Saponin and Saponin Monomer Components on Nerve Cell Damage

[0072] 1. Monomer composition on Aβ 25～35 Protective effect of induced AD cell model

[0073] 1.1 Experimental materials

[0074] PC12 cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences; Aβ25-35 (Sigma-Aldrich, A4459038M4822V, USA); Fetal bovine serum (Gibico, 10437028 1896732, Mexico Origin); Horse Serum (Gibico, 16050122, New Zealand Origin); RPMI Medium 1640 basic (Gibco, 8118262, China); Penicillin-Streptomycin Liquid (Solarbio, P1400 20180907, China); Poly-L-lysine Solution, 10× (Solarbio, P2100 20180115, China); MTT (Solarbio, M8180829Z051); DMSO (Solarbio, D8370 520C0320, China); PBS (Solarbio, P102020180910, China). Annexin V-FITC / Hoechst33342 Cell Apoptosis Detection Kit (Beibo Bio, Lot No.: BB130082). β-Actin Mouse Monoclonal Antibody (affinity, T0022); Bax Antibody (CellSignaling, 0012); Anti-Bcl2 antibody...

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PUM

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Abstract

The invention discloses application of polygonatum sibiricum steroid saponin and polygonatum sibiricum steroid sapogenin in preparation of a drug for treating or preventing Alzheimer's disease. The polygonatum sibiricum steroid saponin and polygonatum sibiricum steroid sapogenin have the structure as shown in the specification, wherein R1 represents C1-C6 alkyl or alkenyl, and R2 represents H or monosaccharide or oligosaccharide. Pharmacological activity research results show that the polygonatum sibiricum steroid saponin and the polygonatum sibiricum steroid sapogenin have good effects of preventing and treating senile dementia.

Description

technical field [0001] The invention belongs to the field of development and utilization of traditional Chinese medicines, and in particular relates to a new huangjingsterol B, its preparation method and application. Background technique [0002] Polygonatum is one of the traditional Chinese medicines that are both food and medicine newly promulgated by the National Health and Family Planning Commission in 2016. It has the functions of nourishing qi and nourishing yin, invigorating the spleen, moistening the lungs, and nourishing the kidney. Dry mouth and lack of food, dry cough due to lung deficiency, overworked cough and hemoptysis, insufficient essence and blood, soreness of waist and knees, premature graying of beard and hair, internal heat and thirst, etc. It is traditionally believed that if Polygonatum is not processed or processed unreasonably, it may cause certain side effects, and Rhizoma Polygonatum should not be used clinically but Rhizoma Polygonatum should be p...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/7048A61P25/28C07J71/00
CPCA61K31/7048A61K31/58C07J71/0005A61P25/28
Inventor 吴毅黄丽萍袁铭铭宁火华殷海霞邬秋萍丁银平潘蕾
Owner 江西省药品检验检测研究院
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