New application of caveolin-1

A technology of caveolin and new use, applied in the field of new use of caveolin-1, which can solve the problem of not finding caveolin and other problems

Inactive Publication Date: 2019-12-10
HUZHOU CENT HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • New application of caveolin-1
  • New application of caveolin-1

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[0009] Materials and Methods

[0010] Main instruments and reagents

[0011] PCR instrument (Biometra, Germany), microtome (Leica, Germany), biological microscope (Nikon 80i, Japan), JD80l gel imaging and analysis system and morphological image analysis system (Jetta, Jiangsu), arteriovenous needle BD0.7 mm (Suzhou BD Medical Instrument Company). LPS (0lll:B4, Sigma, USA), DEX (Jiangsu Hengrui Pharmaceutical Company, batch number: 16060132), TrizoI reagent (Invitrigen, USA), ELISA kit (Hangzhou Lianke Biotechnology Company, batch number: 70-EK3822 / 2) , RIPA lysate (Beyond Institute of Biotechnology, Shanghai), AMV reverse transcription kit, Taq enzyme, dNTP (Promega, USA), Cav-1 PCR primer, TLR-4 PCR primer, P38MAPK primer, internal reference GAPDH primer ( Shanghai Sangong Technology Co., Ltd., Shanghai), rabbit anti-mouse Cav-1 polyclonal antibody Abcam, UK), immunohistochemistry kit (Zhongshan Jinqiao, Beijing), and other reagents are domestic analytical reagents.

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Abstract

The invention belongs to the technical field of biomacromolecules, and relates to a new application of caveolin-1. The caveolin-1 is used for prognosis evaluation of lung protection of ALI, and is more particularly used for preparing an ALI prognosis evaluation reagent or kit. A foundation is provided for diagnosis and treatment of acute lung injury.

Description

technical field [0001] The invention belongs to the technical field of biological macromolecules and relates to a new application of caveolin-1. Background technique [0002] Acute lung injury (Acute lung injury, ALI) is caused by a variety of reasons, based on diffuse lung cell damage, characteristic pathological changes in lung tissue structure, pulmonary edema and pulmonary atelectasis as pathological features, rapidly affecting gas Exchange function is the clinical hallmark of pulmonary inflammation and increased permeability syndrome. Its pathological features are alveolar capillary endothelial cells and alveolar epithelial cell damage, manifested as extensive pulmonary edema and tiny atelectasis. The pathophysiological changes are mainly increased intrapulmonary shunt and decreased lung compliance. Clinically, hypoxemia, rapid respiratory rate, and diffuse infiltration of both lungs appeared on chest X-ray. [0003] Caveolin-1 (cav-1) includes two isoforms, cav-1a a...

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883C12Q2600/118G01N33/6893G01N2800/12
Inventor 孟志鹏刘静陆蕴红童飞胡四平宋鹏涛曹小飞黄新华
Owner HUZHOU CENT HOSPITAL
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