Establishment of Fingerprint of Xingbei Zhike Granules and Its Composition Detection Method

Abstract

The invention relates to the technical field of analytical chemistry, in particular to a method for detecting components of apricot shell cough granules and a method for constructing fingerprints thereof. The detection method comprises: taking Xingbei Zhike Granules for testing and standard products for HPLC detection, and the chromatographic conditions for HPLC detection are as follows: using a C18 chromatographic column, using methanol as mobile phase A, 0.08% formic acid (containing 0.1% ammonium formate) as Mobile phase B, gradient elution; according to the HPLC detection results, the components and contents of Xingbei Zhike Granules were obtained. The spectrum measured by the detection method of the present invention can more comprehensively reflect the chemical components in Xingbei Zhike Granules, and the separation of each chromatographic peak is good, the baseline is stable, the peak shape is good, and the repeatability is good. The method has a good linear relationship, The precision, stability, and recovery rate can accurately detect the component content of Xingbei Zhike Granules, and the obtained control fingerprint can objectively evaluate the quality of the sample.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a method for detecting components of apricot shell cough granules and a method for constructing fingerprints thereof. Background technique [0002] With the rapid development of traditional Chinese medicine preparations in my country, the quality management of traditional Chinese medicine preparations has also received widespread attention, and its quality will directly affect the quality of medical care and the safety of patients. Factors affecting the quality of traditional Chinese medicine preparations mainly include: (1) the quality of the original medicinal materials. The medicine market often obtains a lot of economic benefits from shoddy products. In addition, the supply of wild medicinal materials in my country's medicinal material market is relatively lacking, coupled with the country's restrictions on the collection of wild natural resources. The decline i...

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Problems solved by technology

(3) Process water, clean area environment, and process sanitation. Process water is also an important step in preparation. If the process sanitation and clean area environment are unqualified, it will directly cause the growth and pollution of microorganisms, thereby Lead to substandard products in the produced preparations

(4) Packaging materials and modern packaging technology. The packaging materials of today's preparations are also the key to the quality of preparations. For example, plastics have air permeability and adsorption properties, which can not only ensure the volatilization of the solvent of liquid drugs, but also make them contain volatile components. Changes in performance will accelerate the decomposition of drugs, and the use of inferior security bags will also cause harmful substances to penetrate into the preparations. In addition, due to the characteristics of many dosage forms, various varieties and small production volumes of traditional Chinese medicine preparations, there will be problems caused by packaging bags. Poor quality leads to leakage of liquid preparations, mildew of liquids, reactions between liquid medicines and packaging, and deterioration of solid preparations due to moisture, which seriously affects the quality of preparations

The chemical composition analysis of traditional Chinese medicine is one of the key issues in the elucidation and quality control of effective substances in traditional Chinese medicine. At present, there is no report on the comprehensive chemical composition analysis of Xingbei Zhike Granules

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