Preparation method of artificial blood vessel

An artificial blood vessel, polylactic acid technology, applied in the fields of additive processing, medical science, prosthesis, etc., can solve the problems of inability to adapt to artificial blood vessels, such as pain and suffering, to overcome the lack of blood vessel fineness, stabilize the fiber structure, and inhibit thrombosis. Effect

Pending Publication Date: 2019-12-13
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This problem has been around for a long time, and many patients have to suffer from the pain caused by vascular disease because they cannot adapt to the existing artificial blood vessels

Method used

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  • Preparation method of artificial blood vessel
  • Preparation method of artificial blood vessel
  • Preparation method of artificial blood vessel

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Shark skins were stored at -80°C until use. The frozen fish skin was rinsed with running water to thaw, washed with distilled water, and the residual meat was removed. Wash and cut into small pieces (1.0×1.0cm 2 ). In order to remove non-collagen components, suspend small pieces of fish skin in 0.1mol / L NaOH solution with a material-to-liquid ratio of 1:10, and stir continuously for 6 hours. After the fish skin swells, cut off the outer black rough skin, and use 20% Degrease with ethanol at a ratio of 1:10 to liquid for 24 hours and use 85% ethanol to remove sugar and pigment at a ratio of 1:10 to liquid for 4 hours with continuous stirring, then wash thoroughly with distilled water.

[0036]Prepare the corresponding volume of 0.5mol / L acetic acid solution according to the ratio of material to liquid 1:15. First, take 80% volume of acetic acid solution and soak and stir the pretreated fish skin for 4 hours. The fish skin becomes completely swollen and then homogenized...

Embodiment 2

[0044] Shark skins were stored at -80°C until use. The frozen fish skin was rinsed with running water to thaw, washed with distilled water, and the residual meat was removed. Wash and cut into small pieces (1.0×1.0cm 2 ). In order to remove non-collagen components, suspend small pieces of fish skin in 0.1mol / L NaOH solution with a material-to-liquid ratio of 1:10, and stir continuously for 6 hours. After the fish skin swells, cut off the outer black rough skin, and use 20% Degrease with ethanol at a ratio of 1:10 to liquid for 24 hours and use 85% ethanol to remove sugar and pigment at a ratio of 1:10 to liquid for 4 hours with continuous stirring, then wash thoroughly with distilled water.

[0045] Prepare the corresponding volume of 0.5mol / L acetic acid solution according to the ratio of material to liquid 1:15. First, take 80% volume of acetic acid solution and soak and stir the pretreated fish skin for 4 hours. The fish skin becomes completely swollen and then homogenize...

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Abstract

The invention discloses a preparation method of an artificial blood vessel, which comprises the following steps: preparing a polylactic acid solution by using polylactic acid as a raw material and hexafluoroisopropanol as a solvent; adding collagen sponge from marine organisms into the polylactic acid solution, and preparing a collagen sponge-polylactic acid composite solution; printing the artificial blood vessel at a platform temperature of -35 DEG C to-10 DEG C by adopting a biological 3D printer according to a file with a suffix name of stl output by cartographic software Auto CAD by applying the composite solution, and enabling the shape of the artificial blood vessel to meet the requirement of a target site of a human body to-be-implanted; and performing a cross-linking reaction on the interior of the material of the artificial blood vessel through glutaraldehyde steam. The preparation method is simple, the product is controllable, the prepared artificial blood vessel can be degraded in the human body, the use requirement is met, the replaceable artificial blood vessel can be customized for a patient according to the actual situation of the patient and the operation requirement, and the individuation level is high.

Description

technical field [0001] The invention relates to the field of preparation of medical instruments, in particular to a preparation method of artificial blood vessels. Background technique [0002] Cardiovascular disease, also known as "circulatory system disease", is a common public health problem in the world, which seriously affects the normal life and physical and mental development of human beings. In my country, the risk factors of cardiovascular disease have a very obvious trend of prevalence, which is inseparable from the change of living habits, population aging, environmental factors, etc., which leads to the incidence of cardiovascular disease in my country year by year Increase. At present, the mortality rate of cardiovascular and cerebrovascular diseases has always occupied the top of the death diseases, so the scientific prevention and treatment of cardiovascular diseases is very important. [0003] For the treatment of cardiovascular disease, mainly based on drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/50A61L27/58B33Y10/00
CPCA61L27/18A61L27/24A61L27/507A61L27/58B33Y10/00C08L67/04
Inventor 吴文惠潘涵宇王婷孙宇王江茗蔡旗潘晟旻
Owner SHANGHAI OCEAN UNIV
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