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Preparation method of impurity J of mezlocillin sodium

A technology of mezlocillin sodium and impurities, applied in the field of medicine, can solve the problems of long delivery cycle, high cost, unsuitable for long-term use, etc., and achieve the effects of short preparation cycle, easy operation, and improved quality standards

Inactive Publication Date: 2019-12-20
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For the preparation method of mezlocillin sodium impurity J at present, there is synthesis difficulty, unstable and easy to degrade after synthesis, and a large amount of by-products are easily produced in the synthesis process, the yield is low, the problems such as low purity, foreign commercially available products High cost, cumbersome procedures, long delivery cycle, not suitable for long-term use

Method used

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  • Preparation method of impurity J of mezlocillin sodium
  • Preparation method of impurity J of mezlocillin sodium
  • Preparation method of impurity J of mezlocillin sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add 20mL of acetone solution to 2g of mezlocillin sodium, then add 1.2g of benzoyl peroxide, stir to dissolve, put it in a constant temperature water bath at 30°C for 1.5h, take it out, and spin dry.

Embodiment 2

[0036] Add 30 mL of ethyl acetate solution to 3.5 g of mezlocillin sodium, then add 1.5 g of potassium permanganate, stir to dissolve, put it in a constant temperature water bath at 40°C for 1 hour, take it out, and spin dry.

Embodiment 3

[0038] Add 20mL of acetone solution to 1.2g of mezlocillin sodium, then add 1.0g of potassium permanganate, stir to dissolve, put it in a constant temperature water bath at 35°C for 1.5h, take it out, and spin dry.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a preparation method of an impurity J of mezlocillin sodium. The preparation method comprises the steps: adoptingmezlocillin sodium as a raw material, performing a reaction on the raw material and an oxidant in an organic solvent, and performing spin drying and purification so as to obtain the impurity J of mezlocillin sodium. The novel preparation method of the impurity J of meroxicillin sodium has a short preparation period, easy operation, energy saving, environmental protection and no pollution, and theprepared impurity J of meroxicillin sodium has a purity of 98% or above, can be used as a control standard for quality control, detection and purity improvement of mezlocillin sodium, and can be applied to qualitative and quantitative analysis of impurities during production of mezlocillin sodium, so that the quality standard of mezlocillin sodium is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of mezlocillin sodium impurity J. Background technique [0002] The chemical name of mezlocillin sodium is: (2R,5R,6R)-3,3-dimethyl-6-[(R)-2[3-(methylsulfonyl)-2-oxo-1-imidazole Alkylcarboxamido]-2-phenylacetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic acid sodium salt, its structural formula is as follows: [0003] [0004] Mezlocillin sodium is white or off-white powder or crystal; odorless or slightly specific odor, bitter, hygroscopic. Mezlocillin sodium is a semi-synthetic penicillin antibiotic with broad-spectrum antibacterial activity, and has good antibacterial activity against common Gram-negative and positive bacteria in clinical practice. [0005] Mezlocillin sodium belongs to the β-lactam penicillin antibiotics. Due to the instability of β-lactam, a variety of impurities are inevitably generated during the synth...

Claims

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Application Information

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IPC IPC(8): C07D499/68C07D499/04
CPCC07D499/04C07D499/68
Inventor 苗得足胡清文王志赵征尹诗曾丽丽
Owner REYOUNG PHARMA
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