Lung cancer detection united marker, detection reagent kit and purpose of lung cancer detection united marker

A marker and lung cancer technology, applied in the field of molecular medicine, can solve the problems of decreased quality of life, unsatisfactory survival benefits of patients, and a survival rate of only 14-30%, achieving the effect of improving sensitivity and specificity

Active Publication Date: 2019-12-20
吴一龙 +1
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Problems solved by technology

The use of platinum-based adjuvant chemotherapy is still a widely used adjuvant scheme after non-small cell lung cancer surgery. However, the actual survival benefits of adju...

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  • Lung cancer detection united marker, detection reagent kit and purpose of lung cancer detection united marker
  • Lung cancer detection united marker, detection reagent kit and purpose of lung cancer detection united marker
  • Lung cancer detection united marker, detection reagent kit and purpose of lung cancer detection united marker

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Embodiment Construction

[0037] Nouns and terms:

[0038] The "mutation" described in the present invention includes the following two situations:

[0039] Single nucleotide variation (SNV): caused by a single base substitution, resulting in a change in the encoded amino acid, such as EGFR gene L858R.

[0040] Insertion-deletion mutation (Indel): Multiple base insertions or deletions result in an increase / decrease of encoded amino acids, these types of mutations may be "in-frame", resulting in the addition or decrease of amino acids in proteins, such as exon 19 of the EGFR gene subdeletions; or can result in a "frameshift," often resulting in premature truncation of the protein.

[0041] The definition of "copy number variation" described in the present invention is:

[0042] Copy number variation (CNV): Amplification or deletion occurs in a local region of the chromosome, resulting in overexpression or decreased expression of the encoded protein, such as the amplification of the MET gene.

[004...

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Abstract

The invention relates to a method and purpose of a lung cancer detection united marker, and belongs to the technical field of molecular medicines. The lung cancer detection united marker comprises gene combinations shown as follows: RB1, NKX2-1, CDK4, TP53 and MYC. The method disclosed by the invention has the following advantages that postoperative auxiliary chemotherapy or auxiliary target benefitting situation of EGFR sensitive mutation positive surgical non small-cell lung cancer can be distinguished, after single forecast factors are screened out by a precise statistics method, sensibility and specificity of forecast are improved through a marking model combining a plurality of gene markers, and the marker can be used for guiding selection of postoperative auxiliary treatment schemesof early-period and medium-period lung cancer.

Description

technical field [0001] The invention relates to a combined marker method for detecting lung cancer and its application, belonging to the technical field of molecular medicine. Background technique [0002] Lung cancer is the cancer with the highest mortality rate in the world, and 20-25% of non-small cell lung cancer patients are suitable for radical surgery when they are diagnosed. For these patients, postoperative recurrence is the main reason for clinical treatment failure. It is usually recommended to use a series of adjuvant treatment plans after surgery, including adjuvant chemotherapy, adjuvant targeted drug therapy, etc. to reduce the recurrence rate and death Rate. The use of platinum-based adjuvant chemotherapy is still a widely used adjuvant scheme after non-small cell lung cancer surgery. However, the actual survival benefits of adjuvant chemotherapy to patients are not ideal, and the 5-year survival rate is only 14-30%. The decrease in quality of life caused b...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156C12Q2600/106Y02A90/10
Inventor 吴一龙钟文昭周清邵阳陈烨丹
Owner 吴一龙
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