Double-bionic page-shaped scaffold for bone tendon interface

Abstract

The invention belongs to the technical field of repairing of injury of bone tendon interfaces, in particular to a double-bionic page-shaped scaffold for a bone tendon interface. A preparation method of the double-bionic page-shaped scaffold for the bone tendon interface comprises the following steps: step 1, acquiring normal bone tendon interface tissue samples; and step 2, preparing the double-bionic page-shaped scaffold for the bone tendon interface, exactly, (1), decalcifying the bone tendon interface tissues, (2) preparing the scaffold by adopting page-shaped multilayered tissue slices, and (3), performing decellularization treatment on the bone tendon interface scaffold. By adopting the double-bionic scaffold, structures and matrix components of the tissue can be maintained, and lossof extracellular matrix components also can be avoided to a certain extent, particularly, the loss of biological active ingredients; and moreover, the phenomenon that a decellularization scaffold hasthe excellent traction mechanical performance also can be ensured, and quick and firm anchoring of bones and tendons can be realized. In addition, a decellularization process of the tissues can be effectively quickened, the decellularization time is reduced, and morphological structures and the matrix components of the tissues are maintained preferably.

Description

technical field [0001] The invention belongs to the technical field of repairing bone-tendon interface damage, and in particular relates to a double bionic bone-tendon interface page holder. Background technique [0002] With the vigorous development of national sports and fitness activities, the national physical fitness and health awareness have been steadily improved, but it is inevitable that the incidence of various sports injuries has also increased. Among them, bone-tendon interface injuries (such as cruciate ligament injuries, rotator cuff injuries) are the most common type of sports injuries. According to statistics, in the United States alone, about 250,000 rotator cuff injuries and 100,000 anterior cruciate ligament injuries require surgical treatment each year. Although my country currently lacks relevant epidemiological data, compared with the data in the United States, bone-tendon interface injury has become an urgent challenge in the field of sports medicine ...

AI Technical Summary

Problems solved by technology

However, it is difficult for these multi-phase scaffolds to simulate the dual bionics of the bone-tendon interface morphology and mechanical properties of the organism at the same time, making it difficult for patients to resume sports as soon as possible, and it is difficult to achieve rapid and high-quality healing.

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