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Biphasic tissue engineered scaffolds

A biphasic tissue and engineering technology, used in tissue regeneration, prostheses, coatings, etc., can solve the problems of poor mechanical properties of repair parts, abnormal growth of fibrous tissue, and adverse effects of traditional surgery, so as to improve repair quality and promote regeneration. With the effect of healing, accelerated decellularization process

Active Publication Date: 2022-07-05
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

It is difficult to restore the normal three-layer tissue structure after injury, and the mechanical properties of the repair site are poor. How to improve the repair quality of bone-cartilage interface defects is a major challenge for clinicians.
[0003] At present, surgical treatment such as microfracture, allograft and autograft can improve the quality of defect repair to a certain extent, but there are still obvious limitations to be solved, such as abnormal growth of fibrous tissue at the defect site, infectious diseases, immune rejection, donor There is a shortage of donor organs and pain and degeneration of the donor site, all of which have serious adverse effects on traditional surgery

Method used

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  • Biphasic tissue engineered scaffolds
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Embodiment Construction

[0021] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0022] like Figure 1 to Figure 3 As shown in the figure, an embodiment of the biphasic tissue engineering scaffold of the present invention includes a bone scaffold 1 and a cartilage scaffold 2 that are stacked and integrated in sequence from top to bottom. The other end of 1 is transversely cut with a plurality of bone book pages 12 extending to the bone fixation wrapping part 11, and bone differentiated cell sheets 13 are arranged between the bone book pages 12; one end of the cartilage support 2 is set for cartilage fixation. The wrapping part 21, the other end of the cartilage bracket 2 is transversely cut with a plurality of cartilage book pages 22 extending to the cartilage fixing wrapping part 21, and cartilage differentiation cell sheets 23 are arranged between the cartilage book pages 22; 1. The bottommost bone-based book pag...

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Abstract

The invention discloses a biphasic tissue engineering support, which comprises a bone support and a cartilage support which are stacked and integrated in sequence from top to bottom. The sheet extends to the bone-like book leaf sheet of the bone-fixed wrapping part, and an osteo-differentiated cell sheet is arranged between each bone-like book-like leaf; one end of the cartilage bracket is set as the cartilage-fixed wrapping part, and the other end of the cartilage support is transversely cut with multiple The sheet extends to the cartilage book sheet of the cartilage fixed wrapping part, and a cartilage differentiation cell sheet is arranged between the cartilage book sheets; the bone book sheet at the bottom of the bone support is connected with the cartilage book sheet at the top of the cartilage support. The biphasic tissue engineering scaffold has the advantages of simple preparation, convenient use, reduced decellularization time, and improved repair quality.

Description

technical field [0001] The invention mainly relates to bone-cartilage interface damage repair technology, in particular to a biphasic tissue engineering scaffold. Background technique [0002] Bone-cartilage interface defects caused by trauma, osteochondritis dissociated, chondromalacia patellae, etc. are very common in the field of sports medicine. The osteochondral interface consists of subchondral bone, mineralized fibrocartilage and unmineralized fibrocartilage. constitute. It is difficult to restore the normal three-layer tissue structure after injury, and the mechanical properties of the repair site are poor. How to improve the repair quality of bone-cartilage interface defects is a major challenge for clinicians. [0003] At present, surgical treatment such as microfracture, allogeneic and autologous transplantation can improve the quality of defect repair to a certain extent, but there are still obvious limitations to be solved, such as abnormal growth of fibrous ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/36A61L27/38A61L27/40
CPCA61L27/34A61L27/3608A61L27/3612A61L27/365A61L27/3654A61L27/3817A61L27/3821A61L27/3847A61L27/3852A61L2430/02A61L2430/06C08L89/00
Inventor 吕红斌胡建中瞿瑾周永春
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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