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Cardiovascular and cerebrovascular disease multi-index combined diagnosis method based on combination of portable scanner and microfluidic control filter paper chip

A technology for cardiovascular and cerebrovascular diseases and a diagnosis method, which is applied in the field of multi-index joint diagnosis of cardiovascular and cerebrovascular diseases based on a portable scanner combined with a microfluidic filter paper chip, can solve the judgment error of cardiovascular and cerebrovascular diseases, adverse disease diagnosis, and detection accuracy. Low problems, to achieve the effect of fast detection speed, easy to carry and on-site detection, high detection accuracy

Inactive Publication Date: 2020-01-03
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The specific technical problem to be solved by the present invention is that the existing diagnostic techniques for cardiovascular and cerebrovascular diseases can only be realized by quantitatively detecting a certain index of the human body through expensive large-scale instruments

Method used

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  • Cardiovascular and cerebrovascular disease multi-index combined diagnosis method based on combination of portable scanner and microfluidic control filter paper chip
  • Cardiovascular and cerebrovascular disease multi-index combined diagnosis method based on combination of portable scanner and microfluidic control filter paper chip
  • Cardiovascular and cerebrovascular disease multi-index combined diagnosis method based on combination of portable scanner and microfluidic control filter paper chip

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] The specific implementation example is as follows:

[0033] (1) Fabrication of filter paper substrate: The filter paper is cut according to the designed size to obtain four layers of filter paper and 52 small discs with reaction areas. Subsequently, the four-layer filter paper was subjected to hydrophobic treatment, that is, they were soaked in a hydrophobic solvent made of OTS (octadecyl trifluorosilane) and MTS (methyl trifluorosilane) in a ratio of 1:10 for 5 minutes. After drying, glue the hydrophobically treated filter paper and the small discs together with spray glue.

[0034] (2) Preparation and color reaction of uric acid standard sample: Dilute 1g / L uric acid standard solution into standard samples with concentrations of 1, 2, 4, 6, 8, and 10 mg / dL. Take 200μL of uric acid with different concentrations and 200μL of blank sample, respectively add 1000μL of tungstate protein precipitation agent to them, mix well and wait for 10min, then centrifuge in a centrifuge fo...

Example Embodiment

[0040] Experimental example 1

[0041] Testing the actual samples obtained from Shanxi Provincial Hospital includes the following steps:

[0042] (1) Fabrication of filter paper substrate: The filter paper is cut according to the designed size to obtain four layers of filter paper and 52 small discs with reaction areas. Subsequently, the four-layer filter paper was subjected to hydrophobic treatment, that is, they were soaked in a hydrophobic solvent made of OTS (octadecyl trifluorosilane) and MTS (methyl trifluorosilane) in a ratio of 1:10 for 5 minutes. After drying, glue the hydrophobically treated filter paper and the small discs together with spray glue.

[0043] (2) Divide 1 mL of serum into three equal parts to detect uric acid, glucose and triglycerides;

[0044] (3) Preparation of uric acid standard samples and treatment of actual samples: Dilute 1g / L uric acid standard solution into standard samples with concentrations of 1, 2, 4, 6, 8, and 10 mg / dL. Take 200μL of blank sa...

Example Embodiment

[0049] Experimental example 2

[0050] Testing the actual samples obtained from Shanxi Provincial Hospital includes the following steps:

[0051] (1) Fabrication of filter paper substrate: The filter paper is cut according to the designed size to obtain four layers of filter paper and 52 small discs with reaction areas. Then the four layers of filter paper are hydrophobized, that is, they are soaked in a hydrophobic solvent made of OTS (octadecyl trifluorosilane) and MTS (methyl trifluorosilane) in a ratio of 1:10 for 5 minutes. After drying, glue the hydrophobically treated filter paper and the small discs together with spray glue.

[0052] (2) Divide 1 mL of serum into three equal parts, which are used to detect uric acid, glucose and triglycerides;

[0053] (3) Preparation of uric acid standard sample and treatment of actual sample: Dilute 1g / L uric acid standard solution into standard samples with concentrations of 1, 2, 4, 6, 8, and 10 mg / dL. Take a blank sample, 200μL of uric ...

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Abstract

The invention discloses a cardiovascular and cerebrovascular disease multi-index combined diagnosis method based on combination of a portable scanner and a microfluidic control filter paper chip. According to the invention, whether an object has a risk of suffering from cardiovascular and cerebrovascular diseases is subjected to joint judgment and detection by simultaneously calculating concentration of blood uric acid, blood glucose and triglyceride, comparing the measured concentration values with normal concentration values in a human body and then comparing sizes of difference values; andthe concentration of the blood uric acid, the blood glucose and the triglyceride is obtained by joint detection of the micro control filter paper chip, the scanner, an SD storage card with a Wi-Fi module and a smartphone. The method disclosed by the invention is based on joint analysis of three indexes closely related to the cardiovascular and cerebrovascular diseases and meanwhile, uses the portable scanner and the smartphone which are widely used, and both the portable scanner and the smartphone respectively have accurate image reduction capacity and an image analysis function, and thus, themethod has the obvious advantages of high diagnosis accuracy, high detection speed, high portability, high detection accuracy and easiness for popularization.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a multi-indicator joint diagnosis method for cardiovascular and cerebrovascular diseases based on a portable scanner combined with a microfluidic filter paper chip. The controlled filter paper chip combined with portable scanners and smart phones can detect the respective concentrations, and compare their concentrations with normal human body concentrations to achieve the purpose of diagnosing cardiovascular and cerebrovascular diseases. Background technique [0002] The prevalence of cardiovascular disease in China is on the rise. One of the reasons for the high mortality rate of cardiovascular and cerebrovascular diseases is that patients cannot accurately diagnose the disease in the early stage of the disease, especially in rural areas. The relatively backward medical level increases the difficulty of early diagnosis of cardiovascular and cerebrovascular diseases. [0003] ...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N21/84B01L3/00
CPCB01L3/5027G01N21/78G01N21/8483
Inventor 李晓春侯鹏飞张校亮于化忠
Owner TAIYUAN UNIV OF TECH
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