Functionalized scaffold to promote meniscus repair

A technology derived from meniscus and platelets, applied to medical preparations containing active ingredients, bone/connective tissue cells, prostheses, etc., can solve the problems of tissue availability and limited indications of allografts

Inactive Publication Date: 2020-01-03
THE SCRIPPS RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of allografts is limited by tissue availability and limited indications

Method used

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  • Functionalized scaffold to promote meniscus repair
  • Functionalized scaffold to promote meniscus repair
  • Functionalized scaffold to promote meniscus repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] overall plan

[0065] Forceful twisting, rotation, or excessive flexion of the knee joint can cause a traumatic tear of the meniscus. A meniscal tear can cause knee pain, swelling, stiffness, and limited knee extension. Current surgical approaches to address meniscus tears include sutures and meniscectomy. However, meniscal tears in the avascular region of the medial third typically do not heal spontaneously or after surgery and are a major risk factor for the development of knee osteoarthritis (OA). The middle and inner area of ​​the meniscus lacks blood supply and is therefore least likely to heal.

[0066] Cells that promote meniscal repair and regeneration are present in the menisci adjacent to the tear, as well as in the synovium and joint capsule. Therefore, application of chemokines to the tear site can potentially recruit cells that mediate repair. Growth factors have the potential to promote meniscal healing, and various approaches have been pursued, includ...

Embodiment 2

[0070] acellular meniscal graft

[0071] As is known to those skilled in the art, meniscus tears are the most common knee injury; although some treatments currently exist for meniscus injuries, these treatments do not result in repair or regeneration of the meniscus. In some instances, a partial or total meniscectomy is performed to treat the patient. These treatments often result in patients with osteoarthritis and / or scar tissue.

[0072] In various embodiments, the inventors have addressed this problem by developing chemotactic acellular meniscal grafts for integrative meniscal healing. In one embodiment, the inventors characterized a decellularized meniscus scaffold (DMS) for host cell infiltration. Decellularized native meniscus tissue is a promising bioscaffold for the repair of damaged human menisci. It has similar biological and mechanical properties to the natural meniscus. In addition, ideal scaffolds also contain chemokines to recruit new cell populations to ini...

Embodiment 3

[0077] significance

[0078] The bulk of the meniscus is a fibrocartilaginous meniscus-shaped structure that sits on the periphery of the joint between the tibia and femur. The two anterior and posterior horns connect to the tibial plateau. The menisci provide cushioning by translating compressive and tensile hoop stresses that are weakened at the tibial plateau by the fibrocartilaginous tendon endings.

[0079] A meniscus tear is the most common knee injury. Normal menisci and abnormally developed menisci, especially discoid menisci, are at increased risk of tearing. Even stable discoid menisci can present mechanical symptoms of a meniscus tear. A number of conditions are associated with anterior cruciate ligament (ACL) injuries, such as chronic ACL insufficiency and acute ACL rupture. Different injury patterns may be associated with different risk factors such as sex, age, body weight, and injury mechanism. Although the outer third of the meniscus is potentially healing...

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Abstract

Provided herein is a scaffold comprising a decellularized meniscus tissue, wherein the scaffold is covalently conjugated with heparin and a growth factor. Also provided herein is a method of repairingand / or treating a tissue injury in a subject in need thereof, comprising: providing a scaffold comprising a decellularized meniscus tissue; and repairing and / or treating the tissue injury by implanting the scaffold over the tear, wherein the scaffold is covalently conjugated with heparin and a growth factor.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 472,917, filed March 17, 2017, the entire contents of which are incorporated herein by reference. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with Government support under Grant No. AG007996 awarded by the National Institutes of Health (NIH). The government has certain rights in this invention. technical field [0005] The present disclosure relates to scaffolds and methods of using the scaffolds for tissue repair and / or regeneration. Background technique [0006] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. The following description includes information useful for understanding the present invention. No admission is made...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61L27/38A61L27/54C12N5/077A61P19/00
CPCA61L27/3604A61L27/3683A61L27/3804A61L27/3834A61L27/54A61K35/32A61L2300/236A61L2300/414A61L2300/42A61P19/04A61L27/3654A61L27/3612A61L27/56A61K38/1858A61L2430/06A61K31/727A61L27/24A61L27/3817A61L2300/252
Inventor 马丁·洛茨李光一
Owner THE SCRIPPS RES INST
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