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Noise depth brain stimulation system for Parkinson's disease

A noise and state technology, applied in the field of biomedical engineering, can solve the problems of increasing surgical risks, requiring regular battery replacement, high DBS energy consumption, and achieving the effect of relieving Parkinson's state

Inactive Publication Date: 2020-01-10
TIANJIN UNIV
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Problems solved by technology

However, DBS has the following disadvantages: on the one hand, applying DBS stimulation of about 130Hz, which is the clinical standard, will cause synchronous discharge of neurons in the basal ganglia of the brain at the same frequency, which may bring other negative effects; on the other hand, DBS The energy consumption is high, and the battery needs to be replaced regularly, which greatly increases the risk of surgery

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  • Noise depth brain stimulation system for Parkinson's disease
  • Noise depth brain stimulation system for Parkinson's disease
  • Noise depth brain stimulation system for Parkinson's disease

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Embodiment Construction

[0016] The technical solution of the present invention will be clearly and completely described and explained below in conjunction with the embodiments and the accompanying drawings, but it is not used as a limitation of the protection scope of the present application.

[0017] A novel noise deep brain stimulation system (system for short, see Figure 1-2 ), it is characterized in that the system includes a bidirectional electrode 1, a microcontroller 2, a host computer 3, a noise generator 4 and a filter 5;

[0018] There are two bidirectional electrodes 1, and the bidirectional electrodes 11 and 12 are respectively inserted on the STN nuclei in the left and right basal ganglia of the brain, and have two attributes of acquisition and stimulation. Acquisition of local field potentials (LFPs) of thalamic nucleus (STN) nuclei and application of noise stimulation, and the bidirectional electrode 1 can transmit the acquisition signal to the microcontroller 2;

[0019] The micro-c...

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Abstract

The invention relates to a noise depth brain stimulation system for Parkinson's disease. The noise depth brain stimulation system is characterized by consisting of a bidirectional electrode, a microcontroller, an upper computer, a noise generator and a filter, wherein the bidirectional electrode has two attributes of collection and stimulation, collection of a subthalamic nucleus (STN) nucleus local field potential (LFPs) and application of noise stimulation are respectively realized by setting the attributes of the electrode on the upper computer, and the bidirectional electrode can transmita discharge signal to a microcontroller; a Parkinson's disease state grade distribution table is stored in the upper computer, the table is divided into ten grades according to RI values, if a RI value is smaller, the Parkinson's disease state is more serious, grade classification is conducted on the current Parkinson's disease state according to the table, the parameters corresponding to noise stimulation are extracted, and the parameters are transmitted to the noise generator and the filter.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a novel noise deep brain stimulation system for Parkinson's state. Background technique [0002] Parkinson's disease is caused by the lack of a neurotransmitter called dopamine in the brain. The lack of dopamine will cause changes in the firing rate and firing pattern of neurons, accompanied by the appearance of beta frequency bands in neurons in the basal ganglia of the brain (12 -35Hz) synchronous discharge phenomenon. Pathological synchronous discharge phenomenon will seriously affect the ability of the thalamus to respond to external stimuli, that is, the reliability of the thalamus will be reduced, so Parkinson's patients will appear symptoms such as resting tremor, slow movement, and inability to move. The existing method for relieving the above symptoms is mainly based on deep brain stimulation (DBS), which can effectively weaken the synchronous discharge phenomenon ...

Claims

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Application Information

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IPC IPC(8): A61B5/0476A61N1/36
CPCA61B5/6847A61N1/36067A61B5/369
Inventor 于海涛孟紫寒刘晨王江刘静张志勇朱晓东张伟李琪刘葳
Owner TIANJIN UNIV
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