Vaginal expansion suppository containing probiotics and traditional Chinese medicine composition, and preparation method thereof
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A technology of vaginal expansive suppositories and compositions, applied in the field of vaginal expansive suppositories and its preparation, can solve the problems of destroying normal vaginal flora, increasing drug resistance, and low bioavailability of suppositories, so as to improve the environment of vaginal flora, maintain Microecological health, avoiding the effect of repeated attacks
Active Publication Date: 2020-01-14
HARBIN OT PHARMA +1
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Among them, antibiotics have a positive effect on disease control, but the extensive use of antibiotics will reduce the sensitivity of bacteria to drugs and increase drug resistance, and antibiotics can destroy the normal vaginal flora while inhibiting pathogenic bacteria; follow-up research results showed that the recurrence rate after 12 months in patients treate...
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Embodiment 1
[0072] This embodiment provides a vaginal expansive suppository containing probiotics and a traditional Chinese medicine composition, the composition of which is as follows:
[0073]
[0074] The preparation method is as follows:
[0075] (1) mixing the matrix components and melting them in a water bath heating pot to obtain a matrix melt;
[0076] (2) mixing the components in the traditional Chinese medicine composition, decocting in conventional water, concentrating, freeze-drying, and pulverizing to obtain the Chinese medicine composition;
[0077] (3) mixing and dispersing the matrix melt obtained in step (1) with probiotics and traditional Chinese medicine composition at room temperature to obtain a drug-containing matrix;
[0078](3) Put the drug-containing matrix obtained in step (2) into a suppository mold, insert the expansion carrier, cool and shape, and obtain 100 vaginal expansible suppositories, each with a mass of about 3.7 g.
Embodiment 2
[0080] This embodiment provides a vaginal expansive suppository containing probiotics and a traditional Chinese medicine composition, the composition of which is as follows:
[0081]
[0082] The preparation method was the same as that in Example 1, and 75 vaginal expansion plugs were obtained, each weighing about 3.4 g.
Embodiment 3
[0084] This embodiment provides a vaginal expansive suppository containing probiotics and a traditional Chinese medicine composition, the composition of which is as follows:
[0085]
[0086] The preparation method was the same as in Example 1, and 150 vaginal expansion suppositories were obtained, each with a mass of about 3.6 g.
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Abstract
The invention provides a vaginal expansion suppository containing probiotics and a traditional Chinese medicine composition, and a preparation method thereof. The vaginal expansion suppository comprises an expansion carrier and a drug-containing matrix coating the surface of the expansion carrier; the drug-containing matrix comprises probiotics, the traditional Chinese medicine composition and a matrix; the probiotics comprise lactic acid bacteria and bifidobacteria; the traditional Chinese medicine composition comprise cortex phellodendri, radix sophorae flavescentis, fructus cnidii, folium artemisiae argyi, radix scutellariae, radix astragali, rheum officinale and ginseng. According to the vaginal expansion suppository disclosed by the invention, through an administration form of combining medicinal components with the expansion carrier, full contact between the suppository and a lesion part and absorption of the lesion part on medicines are promoted, so that the vaginal expansion suppository is high in stability and good in curative effect; and the synergistic compounding of the effective medicinal components probiotics and the traditional Chinese medicine composition promotes the growth and proliferation of effective microbial floras in the vagina, and inhibits and eliminates pathogenic bacteria in a broad-spectrum manner, so that the vagina microbial community environmentis thoroughly improved, and the micro-ecological health in the vagina is maintained.
Description
technical field [0001] The invention belongs to the technical field of vaginal suppositories, and in particular relates to a vaginal expansive suppository containing probiotics and a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Reproductive tract infection is a common disease in gynecology. Reproductive tract infection in a narrow sense generally refers to lower genital tract infection, especially vaginitis. According to a survey on the reproductive health status of Chinese women hosted by the Maternal and Child Health Center of the Chinese Center for Disease Control and Prevention, about 53% of adult women have suffered from vaginitis in one year, and nearly 10% of them have recurrent episodes for 4 Moreover, the initial origin of gynecological malignancies such as uterine fibroids and cervical cancer is often genital tract infection; in addition, if genital tract infection cannot be detected and treated in time, i...
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