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Use of specific lectin in preparation of test tools for verifying lung cancer types, and device

A testing tool, lectin technology, applied in measurement devices, instruments, fluorescence/phosphorescence, etc., can solve the problems of high false positive rate, low detection rate, unsatisfactory application effect, etc., to achieve high organ specificity, reduce testing cost effect

Pending Publication Date: 2020-01-17
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, the methods used in clinical diagnosis of lung cancer mainly include imaging, cytopathology and serological index examination. The actual clinical application effect is not ideal, especially the early diagnosis value is limited

Method used

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  • Use of specific lectin in preparation of test tools for verifying lung cancer types, and device
  • Use of specific lectin in preparation of test tools for verifying lung cancer types, and device
  • Use of specific lectin in preparation of test tools for verifying lung cancer types, and device

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Experimental program
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Embodiment Construction

[0025] The relevant verification experiments and analysis of the present application are introduced below, and the inventor's specific research and development process is not limited thereto; the specific examples given are not intended to limit the present application.

[0026] The present application screens lectin probes for identifying lung cancer patients from 37 lectins (as shown in Table 1).

[0027] Table 1 Names of 37 lectins

[0028]

[0029]

[0030] The reagent materials mainly used in this application are shown in Table 2, and the rest of the commonly used reagents are of domestic analytical grade; the instruments and equipment are shown in Table 3, and the rest of the commonly used instruments and equipment are all made in China.

[0031] Table 2 Reagents and materials used in experiments

[0032]

[0033]

[0034] Table 3 Instruments and equipment used in the experiment

[0035]

[0036] 1. Study population and collection of bronchoalveolar lava...

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Abstract

The invention provides a use of specific lectin in the preparation of test tools for verifying lung cancer types, and a device. In view of a sample taken from bronchoalveolar lavage fluid, the specific lectin can be divided into two groups: the group A contains PHA-E, EEL, BPL, GSL-II, VVA and PNA for judging whether the sample is from a patient with adenocarcinoma of lung; the group B contains PNA and MPL for judging whether the sample is from a patient with squamous cell lung carcinoma; and if it is known in advance that the subject is a patient with lung cancer, whether the sample is from apatient with small cell lung cancer can be deduced according to the test results of the group A and the group B. According to the use provided by the invention, the bronchoalveolar lavage fluid is used as an object to be detected, since the object to be detected is a sample obtained directly from the primary lesion and adjacent tumor cells, the object to be detected has high organ specificity, can directly reflect the true state of the body of the patient, and is safe and minimally invasive.

Description

technical field [0001] The invention relates to a technique for identifying lung cancer types based on glycoprotein glycoforms, and specifically relates to the use of specific lectins in making test tools and corresponding devices. Background technique [0002] Lung cancer is one of the most common malignant tumors, which seriously endangers human health. Its morbidity and lethality rank first among all malignant tumors. The reports "Global Cancer Statistics 2018" and "Cancer Incidence and Mortality in China in 2014" show that the incidence and mortality of lung cancer account for 11.6% and 18.4% (global), 20% and 27.3% of the total cancer population. %(China). [0003] Lung cancer can generally be divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (Small cell lung cancer, SCLC). According to different pathological features, NSCLC mainly includes lung adenocarcinoma (Adenocarcinoma, ADC) and lung squamous carcinoma (Squamous carcinoma, SCC). The in...

Claims

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Application Information

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IPC IPC(8): G01N33/535G01N33/533G01N21/64G01N33/574
CPCG01N21/6428G01N33/533G01N33/535G01N33/57423G01N33/57484G01N2021/6439
Inventor 陈明伟刘丽娜郭炫李铮陈天君张宸
Owner XIAN MEDICAL UNIV
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