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Taylor Diffusion Analysis Apparatus and Method for Determining the Size of Substances in Solution

A technology of diffusion analysis and structural analysis, applied in the direction of measuring devices, analysis materials, material separation, etc., can solve the problems of low analysis efficiency, achieve improved ability, and meet the effect of high-throughput analysis

Active Publication Date: 2021-01-05
福特斯(北京)科技有限公司
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Problems solved by technology

Traditional Taylor diffusion analysis usually analyzes the degree of diffusion of substances with a single-component structure, but this method will lead to low analysis efficiency

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  • Taylor Diffusion Analysis Apparatus and Method for Determining the Size of Substances in Solution
  • Taylor Diffusion Analysis Apparatus and Method for Determining the Size of Substances in Solution
  • Taylor Diffusion Analysis Apparatus and Method for Determining the Size of Substances in Solution

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Embodiment Construction

[0032]In order to make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of the embodiments of the present invention, not all the embodiments. The components of the embodiments of the present invention generally described and illustrated in the drawings herein may be arranged and designed in various different configurations.

[0033]Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary...

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Abstract

The invention, which relates to the technical field of analysis of substances in liquid-phase media, provides a Taylor diffusion analysis device and a method for measuring the size of a substance in asolution. The device comprises a microfluidic channel. A to-be-measured sample is divided into at least two parts by at least two microfluidic channel branches with different lengths in the microfluidic channel; and at least two parts of to-be-measured sample flow through the at least two parts by at least two microfluidic channel branches respectively and then mass spectrometric detection is performed. Therefore, taylor diffusion analysis and mass spectrum detection of a multi-component to-be-detected sample are completed at the same time and size measurement can be carried out on various components separated by a liquid phase analysis method, so that the continuous analysis capacity of the system is improved, and the requirement for high-throughput analysis is met.

Description

Technical field[0001]The invention relates to the technical field of substance analysis in a liquid medium, in particular to a Taylor diffusion analysis device and a method for measuring the size of substances in a solution.Background technique[0002]Taylor dispersion analysis (TDA, Taylor dispersion analysis) is an analysis method that uses a capillary as a channel in a liquid environment to determine the hydrodynamic radius of a single substance in a liquid environment based on the diffusion characteristics of the substance. Due to the lack of complex system multi-component structure analysis Ability, and the correction process is more complicated, it is difficult to achieve wide application.[0003]In Taylor's diffusion analysis experiment, constant pressure / velocity fluid is used to drive the analyte in the laminar flow, and the analysis of the degree of diffusion of the analyte is realized through the detector, which is easily realized on the commercial capillary electrophoresis (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/72G01N30/86
CPCG01N30/7266G01N30/7293G01N30/8634
Inventor 不公告发明人
Owner 福特斯(北京)科技有限公司
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