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A kind of in vitro release model and in vitro release method of propofol fat emulsion injection

A technology of propofol fat and injection, which is applied in the direction of testing pharmaceutical preparations, instruments, measuring devices, etc., can solve the problem of low release amount, achieve the effect of increasing release rate, ensuring stability, and increasing release rate

Active Publication Date: 2021-05-25
江苏盈科生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the PBS buffer containing 1% SDS, and after the optimization of the test program, the release amount can reach 40% in 48 hours, but the release amount is still low

Method used

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  • A kind of in vitro release model and in vitro release method of propofol fat emulsion injection
  • A kind of in vitro release model and in vitro release method of propofol fat emulsion injection
  • A kind of in vitro release model and in vitro release method of propofol fat emulsion injection

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Experimental program
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Embodiment Construction

[0017]The present invention will be further described below in connection with the embodiments:

[0018]In vitro release model of propofol fatty milk injection, including a closed test vessel, a closed test vessel has a release medium, and the closed test vessel is placed in a full-temperature oscillating incubator. Among them, the release medium is 20 to 70% ethanol, aqueous aqueous aqueous aqueous aqueous solution, aqueous methanol, aqueous solution, aqueous aqueous solution.

[0019]In vitro release method of propofol fatty milk injection, the release medium is released from 20 to 70% aqueous ethanol solution, and a reverse osmolating method is taken through a constant temperature oscillation incubator in a closed test vessel and shake and shake. The temperature was controlled at 37 ± 0.5 ° C, the oscillation frequency was 50 to 100 rpm / min.

[0020]The release medium may also be 20 to 70% aqueous aqueous aqueous acetonitrile, methanol aqueous solution, isopropanol aqueous solution, aqu...

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Abstract

The invention discloses an in vitro release model and an in vitro release method of propofol fat emulsion injection, and belongs to the field of in vitro release models. The in vitro release model includes a closed test vessel, which is equipped with a release medium, and the closed test vessel is placed in the whole in a warm shaking incubator. The in vitro release method is to select the release medium, adopt reverse osmosis analysis method, and carry out constant temperature control and shaking in a closed test vessel through a constant temperature shaking incubator. The invention significantly improves the release rate, reaching more than 90%.

Description

Technical field[0001]The present invention relates to the field of in vitro release model, in particular, in vitro release model and in vitro release method of propofol fatty milk injection.Background technique[0002]Drug research research and development process requires providing drugs in vitro release research data. Most of the foreign release models for solid preparations, China Pharmaceutical Condom has been related to relevant guidance, but the research methods for fatty milk injection have not given guidance recommendation. Referring to the related art, use the simulated human physiological conditions for research, the method is: the method is: the dialysis method is performed outside the body, the release medium is selected is a buffer of physiological pH, and a certain proportion of dodecyl sulfate (SDS) or Tween 80 is added. As the release medium for research.[0003]Existing in vitro release models typically be used as a release medium in a phosphate buffer (PBS), and the sa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15G01N30/88
CPCG01N30/88G01N33/15
Inventor 李海杨亚勇黄芳
Owner 江苏盈科生物制药有限公司