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Blood purification material and preparation method based on mussel biomimetic chemistry

A technology of blood purification and biomimetic chemistry, applied in the fields of biochemical separation and biomedical materials, can solve the problems of low adsorption force and easy falling off of substrates, and achieve the effect of super waterproof adhesion and universal adhesion

Active Publication Date: 2022-08-05
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing substrates used to prepare blood purification materials are porous materials such as carbonized resins and adsorbent resins, and these materials are usually cross-linked structures with few modifiable groups themselves. Aldehyde (PVB) directly coats porous materials such as carbonized resin and adsorption resin, and the formed coating film has a small adsorption force for the substrate and is easy to fall off

Method used

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  • Blood purification material and preparation method based on mussel biomimetic chemistry
  • Blood purification material and preparation method based on mussel biomimetic chemistry

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Effect test

Embodiment 1

[0023] A blood purification material based on mussel biomimetic chemistry, the blood purification material is a porous adsorption substrate, an adsorption layer and a coating film in sequence from the inside to the outside, and the adsorption layer is a polylysine hydrochloride adsorption layer, And polylysine hydrochloride is wound on the porous adsorption substrate in the form of molecular chains; the coating film is a polyvinyl butyral-gallic acid film; and the porous adsorption substrate is a carbonized resin.

[0024] The preparation method of the above-mentioned blood purification material comprises the following steps:

[0025] (1) Coating polylysine hydrochloride solution on carbonized resin to form polylysine hydrochloride adsorption layer, wherein the mass fraction of polylysine hydrochloride solution is 20%, and the carbonized resin The pore size is 2-50nm, and the specific surface area of ​​the porous adsorption substrate is >500m 2 / g;

[0026] (2) put the carbo...

Embodiment 2

[0028] A blood purification material based on mussel biomimetic chemistry, the blood purification material is a porous adsorption substrate, an adsorption layer and a coating film in sequence from the inside to the outside, the adsorption layer is a polymyxin sulfate adsorption layer, and Polymyxin B sulfate is wound on the porous adsorption substrate in the form of molecular chains; the coating film is a polyvinyl butyral-gallic acid film; and the porous adsorption substrate is a carbonized resin.

[0029] The preparation process of the above-mentioned blood purification material comprises the following steps:

[0030] (1) Coating polymyxin B sulfate (PMB) solution on carbonized resin to form a polymyxin sulfate adsorption layer, wherein the mass fraction of polymyxin B sulfate solution is 5%, and the carbonized resin The pore size is 2-50nm, and the specific surface area of ​​the porous adsorption substrate is >500m 2 / g;

[0031] (2) put the carbonized resin that has atta...

Embodiment 3

[0033] A blood purification material based on mussel biomimetic chemistry, the blood purification material is a porous adsorption substrate, an adsorption layer and a coating film in sequence from the inside to the outside, the adsorption layer is polyethyleneimine, and the polyethyleneimine It is wound on the porous adsorption base material in the form of molecular chains; the coating film is a polyvinyl alkyd butyraldehyde-gallic acid film, and the porous adsorption base material is a polystyrene divinyl adsorption resin.

[0034] The preparation process of the above-mentioned blood purification material includes the following steps:

[0035] (1) The polyethyleneimine solution is coated on the polystyrene divinylbenzene adsorption resin, and a polyethyleneimine adsorption layer is formed on the polystyrene divinylbenzene adsorption resin, wherein the mass fraction of the polyethyleneimine solution used is is 10%, the pore size of the polystyrene divinyl benzene adsorption re...

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Abstract

The invention discloses a blood purification material based on mussel biomimetic chemistry and a preparation method thereof. The blood purification material is composed of a porous adsorption base material, an adsorption layer and a coating film in sequence from the inside to the outside, and the adsorption layer is Polymyxa sulfate. One or more of B, polylysine hydrochloride, polyethyleneimine or polydopamine, and is wound on the porous adsorption substrate in the form of molecular chains; the coating film is polyethylene Butyral-gallic acid film or polyvinyl butyral film. The blood purification material is designed based on mussel biomimetic chemistry, and has the advantages of simplicity and convenience, mild conditions, environmental protection, and basically no influence on the material body, and the blood purification material is used in the field of blood purification medical devices.

Description

technical field [0001] The invention belongs to the field of biochemical separation and biomedical materials, and particularly relates to a blood purification material based on mussel biomimetic chemistry and a preparation method thereof. Background technique [0002] At present, in the preparation process of blood purification medical device materials, it is often necessary to modify the adsorbent. The coating materials usually include PVB, collodion, etc., such as improving their blood compatibility by physical coating, or by chemical reaction. Immobilization improves its adsorption capacity. However, most of the existing substrates used to prepare blood purification materials are porous materials such as carbonized resins and adsorption resins, and these materials are usually cross-linked structures with few modifiable groups themselves. Therefore, polyvinyl butyral Aldehyde (PVB) directly coats porous materials such as carbonized resin and adsorption resin, and the form...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/24B01J20/26B01J20/28B01J20/30B01J20/32B01D15/00
CPCB01J20/24B01J20/262B01J20/261B01J20/28021B01J20/28033B01J20/28083B01J20/28064B01J20/3085B01J20/3202B01J20/3289B01D15/00B01J2220/4856
Inventor 李设桥姜建明
Owner 佛山市博新生物科技有限公司
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