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Apparatus for radiopharmaceutical quantification of a body part

A technology of radiopharmaceuticals and body parts, applied in the fields of radiodiagnostic instruments, applications, medical science, etc., which can solve problems such as low photon emission rate and low activity

Active Publication Date: 2020-03-24
BAYER AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such gamma-ray imaging poses specific problems even for single radionuclides due to, for example, the low photon emission rates of radionuclides, and the inclusion in the measurement data of large background photons from cosmic and terrestrial sources contribution, e.g. when administering very low activity on the order of 1 MBq to a patient

Method used

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  • Apparatus for radiopharmaceutical quantification of a body part
  • Apparatus for radiopharmaceutical quantification of a body part
  • Apparatus for radiopharmaceutical quantification of a body part

Examples

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example 1

[0164]Example 1. An apparatus for dosing radiopharmaceuticals to a body part comprising:

[0165] - input unit; and

[0166] - processing unit;

[0167] Wherein the input unit is configured to provide at least one photon image of the body part to the processing unit;

[0168] Wherein at least one photon image is acquired by at least one photon camera configured to detect gamma rays and / or X-rays;

[0169] wherein at least one photon image includes spectral energy data including data resulting from decay of at least one radiopharmaceutical;

[0170] Wherein the input unit is configured to provide the processing unit with characteristic photon emission energies and emission probabilities associated with decay of at least one radiopharmaceutical;

[0171] wherein the processing unit is configured to determine the activity of at least one radiopharmaceutical at a plurality of spatial orientations in the body part,

[0172] wherein the determination of the spatial orientation o...

example 2

[0175] Example 2. The apparatus according to example 1, wherein the input unit is configured to provide at least one radiopharmaceutical decay half-life to the processing unit, and wherein the generation of the composite spectrum comprises utilization of the at least one radiopharmaceutical decay half-life.

example 3

[0176] Example 3. The device according to any of examples 1-2, wherein the at least one radiopharmaceutical comprises a first radiopharmaceutical and a second radiopharmaceutical.

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Abstract

The present invention relates to an apparatus for radiopharmaceutical quantification of a body part. It is described to provide (210) a processing unit (30) with at least one gamma image of a body part. The at least one gamma image was acquired by at least one gamma camera configured to detect gamma rays and / or X-rays. The at least one gamma image comprises spectral energy data that comprises datathat has resulted from the decay of at least one radiopharmaceutical. The processing unit is provided (220) with characteristic photon emission energies and emission probabilities associated with thedecay of the at least one radiopharmaceutical. The processing unit determines (230) an activity of the at least one radiopharmaceutical at a plurality of spatial positions in the body part. The determination for a spatial position of the plurality of spatial positions comprises generating (240) a synthetic spectrum and correlating the generated synthetic spectrum to an experimental spectrum generated from the spectral energy data for at least one position in the at least one gamma image that corresponds to that spatial position. Generating the synthetic spectrum comprises utilising the photonemission energies and emission probabilities associated with the decay of the at least one radiopharmaceutical. The processing unit determines (250) a spatial distribution of the at least one radiopharmaceutical in the body part.

Description

technical field [0001] The invention relates to a device for the radiopharmaceutical dosing of a body part, a system for the radiopharmaceutical dosing of a body part, a method for the radiopharmaceutical dosing of a body part as well as a computer program element and a computer readable medium. Background technique [0002] The general background of the invention is quantitative gamma camera imaging of patients. Radiopharmaceuticals can be used in the treatment of patients. Radiopharmaceuticals, such as one or more radionuclides, can be obtained by the patient in vivo, eg, intravenously or orally. Radiopharmaceuticals, such as radionuclides, can be used in the detection of specific diseases, and indeed in the targeted therapy of diseases, where alpha / electron / beta emission can be used to destroy targeted tissue cells. (For ease of explanation, the following discussion refers to radionuclides in specific sections, however, such discussion also applies to radiopharmaceutica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03A61B6/00
CPCA61B6/037A61B6/4057A61B6/4258A61B6/5205A61B6/5282A61B6/481G06T7/0012G06T2207/10116
Inventor C.欣多夫E.拉松G.布罗林T.奥尔松
Owner BAYER AG
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