Use of rhamnose and derivatives thereof as antifungal agents

Through the combination of rhamnose-rich polysaccharides and other antifungal agents, the existing problems of high recurrence rate and drug resistance in the treatment of seborrheic dermatitis are solved, an efficient and safe antifungal effect is achieved, and the growth of Malassezia is significantly inhibited. growth and reduces the risk of drug toxicity.

Active Publication Date: 2020-03-31
ISDIN CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above treatments exist, they are often not fully satisfactory due to the high recurrence rate of superficial skin mycosis
Furthermore, in some cases, these compounds exhibit inherent toxicity, limiting their applicability
There are still a large number of patients who do not benefit from treatments using current technologies, either because they do not respond to treatment or because they cannot tolerate a particular treatment
In addition, the frequent use of antifungal agents in these diseases may lead to the rise of fungal resistance to these drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A cream having the composition shown in the table below was prepared according to a method comprising the following steps:

[0075] 1. Combine Phase A ingredients in the order given, stirring after each addition, until a homogeneous bulk phase is obtained. The bulk phase is then heated to 75°C to 80°C.

[0076] 2. Weigh phase B ingredients, heat to 75°C to 80°C and mix until a homogeneous phase is obtained.

[0077] 3. When the temperature of both phases is between 75°C and 80°C, slowly add phase B to phase A, then homogenize the mixture.

[0078] 4. Cool the mixture obtained in step 3 to 55°C, adjust the pH with sodium hydroxide and add the other ingredients of phase C in the order given, stirring after each addition until a homogeneous bulk phase is obtained.

[0079] 5. Cool the mixture obtained in step 4 to 20°C to 30°C.

[0080]

Embodiment 2 and comparative example 3

[0082] A cream with the composition shown in the table below was prepared according to the method described in Example 1.

[0083]

[0084] Antifungal Activity Test

[0085] Human organotypic skin cultures were obtained from abdominal skin removed during plastic surgery. These skin explants were altered by partial removal of the stratum corneum to facilitate colonization, and MF suspensions were placed on the skin surface and incubated for 24 h under conditions optimal for MF growth. 24 hours after the initial MF inoculation, NSFC was topically applied to the skin explants (2 mg / cm 2 ) and spread evenly. On control skin explants inoculated in the same manner, no product was applied (C2). The sham control group was treated with petrolatum, a neutral cream with no known antifungal properties (P3). MF growth was monitored by quantifying MF colony forming units (CFU) in samples removed from the skin surface. CFUs were quantified by recovering fungal microorganisms from s...

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PUM

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Abstract

The invention relates to a rhamnose or a rhamnose-rich polysaccharide for use in the treatment and / or prevention of fungal infections in human beings. It also relates to a combination of rhamnose or arhamnose-rich polysaccharide and a further antifungal agent for use in the treatment and / or prevention of fungal infections in human beings. It also relates to pharmaceutical or cosmetic compositioncomprising an effective amount of rhamnose or a rhamnose-rich polysaccharide for use in the treatment and / or prevention of fungal infections in human beings.

Description

[0001] This application claims the benefit of European patent application EP17382512.6, filed on July 28, 2017. Technical Field [0002] This invention relates to the use of rhamnose or rhamnose-rich polysaccharides in the treatment and / or prevention of fungal infections in humans, particularly fungal infections caused by *Malassezia* spp. associated with dermatological conditions. It also relates to the use of pharmaceutical and cosmetic compositions containing rhamnose or rhamnose-rich polysaccharides in the treatment and / or prevention of fungal infections in humans. Background Technology [0003] Seborrheic dermatitis (SD) is a common, chronic, relapsing inflammatory skin condition affecting approximately 1% to 3% of the population, mostly adults. SD causes scaly, itchy, and reddened skin on the scalp, eyebrows, nasolabial folds, lips, ears, sternal region, armpits, under the breast folds, navel, groin, and gluteal crease. The condition is characterized by a variety of shap...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/715A61P17/08A61K45/06
CPCA61K45/06A61K31/715A61K2300/00A61P31/10A61K31/4412A61K31/7004
OwnerISDIN CO