Application of serum protein HFREP1 in diagnosis of rheumatoid arthritis disease states

A technology for rheumatoid and disease states, which is applied in the application field of serum protein HFREP1 in the diagnosis of rheumatoid arthritis disease states, and can solve problems such as higher requirements for doctors' experience

Active Publication Date: 2020-04-03
JIANGSU PRECISE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the DAS28 scoring system is a subjective scori

Method used

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  • Application of serum protein HFREP1 in diagnosis of rheumatoid arthritis disease states
  • Application of serum protein HFREP1 in diagnosis of rheumatoid arthritis disease states
  • Application of serum protein HFREP1 in diagnosis of rheumatoid arthritis disease states

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Diagnostic Efficiency of HFREP1 Diagnosis Classification of Rheumatoid Arthritis Patients in Remission and Active Stage

[0013] 1. Experimental samples and reagents

[0014] Test set samples: 34 patients with rheumatoid arthritis in remission and 30 patients with active rheumatoid arthritis were collected from Jiangsu Provincial Hospital of Traditional Chinese Medicine. There was no significant difference in age, gender, and body mass index matching between remission patients and active patients;

[0015] Validation set samples: 26 patients with rheumatoid arthritis in remission and 16 patients with active rheumatoid arthritis were collected from Jiangsu Provincial People's Hospital. There was no significant difference in age, gender, and body mass index matching between remission patients and active patients.

[0016] The inclusion criteria for patients with rheumatoid arthritis in remission and active stages are as follows:

[0017] Refer to the diagnosti...

Embodiment 2

[0054] Example 2: A kit for diagnosing and classifying the active and remission stages of rheumatoid arthritis

[0055] A reagent kit for diagnosing and classifying rheumatoid arthritis active phase and remission phase, which includes ELISA reagent for detecting serum protein HFREP1 content.

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Abstract

The invention discloses an application of serum protein HFREP1 in diagnosis of a rheumatoid arthritis disease state. Disease states of rheumatoid arthritis disease activity scoring systems DAS28 and RA recommended according to European anti-rheumatism alliance are divided into an activity period and a remission period. However, the DAS28 scoring system is a set of subjective scoring system and hashigh requirements for experience of doctors. According to the invention, the serum protein HFREP1 has extremely high diagnostic value in the aspect of diagnosing and distinguishing the active periodand the remission period of rheumatoid arthritis, is high in diagnostic accuracy, is objective and easy to operate compared with the existing DAS28 scoring system, and can be used for preparing a diagnostic kit for diagnosing and distinguishing the active period and the remission period of rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of disease detection and diagnosis, and relates to the application of biomarkers in disease diagnosis, in particular to the application of serum protein HFREP1 in the diagnosis of rheumatoid arthritis disease state. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by erosive arthritis. The incidence rate in our country is 0.2%-0.4%, and it is more common in women. The pathological manifestations are chronic inflammation of the synovial membrane, pannus formation, and cartilage and bone destruction of the joint, eventually leading to joint deformity and loss of function. The current diagnosis of RA refers to the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). EULAR recommended the RA disease activity score system (disease activity score in 28 joints, DAS28). According to this scoring system, the disease state of RA is di...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/102
Inventor 刘史佳周伟纪伟谈文峰郭云柯柯梦颖卢佳微
Owner JIANGSU PRECISE MEDICAL TECH CO LTD
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