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Compositions containing quinolones and uses thereof

A technology of quinolones and compounds, applied in the field of medicine, can solve the problem that the anti-tumor activity of quinolones needs to be further improved

Active Publication Date: 2021-03-26
中山万远新药研发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the above-mentioned patents disclose the effect of quinolones on antitumor, the antitumor activity of quinolones needs to be further improved.

Method used

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  • Compositions containing quinolones and uses thereof
  • Compositions containing quinolones and uses thereof
  • Compositions containing quinolones and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation of the plant extract includes the following steps: drying the plant material at 35°C, crushing through a 35-mesh sieve, adding 10 times the amount (v / w) of water for ultrasonic extraction, repeating the extraction twice for 50 minutes each time, filtering , Concentrate the filtrate to dryness, that is.

Embodiment 2

[0045]The preparation of the plant extract includes the following steps: drying the plant material at 45°C, crushing through a 45-mesh sieve, adding 20 times the amount (v / w) of water for ultrasonic extraction, repeating the extraction 4 times, each time for 70 minutes, and filtering , Concentrate the filtrate to dryness, that is.

Embodiment 3

[0047] The preparation of the plant extract includes the following steps: drying the plant material at 40°C, crushing through a 40-mesh sieve, adding 15 times the amount (v / w) of water for ultrasonic extraction, repeating the extraction 3 times, each time for 60 minutes, and filtering , Concentrate the filtrate to dryness, that is.

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PUM

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Abstract

The invention relates to the technical field of medicine, and in particular relates to a composition containing a quinolone compound and an application of the composition. The composition includes thequinolone compound and an inorganic salt, wherein the inorganic salt includes at least one of chloride and phosphate. The composition has the advantage of an obvious anti-tumor effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition containing quinolones and its application. Background technique [0002] Tumor refers to the neogrowth formed by the proliferation of local tissue cells in the body under the action of various tumorigenic factors, because this neogrowth is mostly in the form of space-occupying blocky protrusions, also known as neoplasm (neoplasm) . Studies have found that tumor cells undergo metabolic changes different from normal cells, and tumor cells themselves can adapt to changes in the metabolic environment through the conversion between glycolysis and oxidative phosphorylation (OXPHOS). According to the cell characteristics of new organisms and the degree of harm to the body, tumors are divided into two categories: benign tumors and malignant tumors. Malignant tumors can be divided into carcinoma and sarcoma. Carcinoma refers to malignant tumors derived from epithelial tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K33/42A61K33/14A61K31/4709A61K31/5383A61K31/47A61K31/496A61P35/00A61P35/02A61K36/45A61K36/537A61K36/07A61K36/27A61K36/254A61K36/185A61K36/82A61K36/37A61K36/8888A61K36/748A61K36/60A61K36/23A61K36/24A61K36/47A61K36/03A61K36/87A61K36/48A61K36/51
CPCA61K31/47A61K31/4709A61K31/496A61K31/5383A61K33/14A61K33/42A61K36/03A61K36/07A61K36/185A61K36/23A61K36/24A61K36/254A61K36/27A61K36/37A61K36/45A61K36/47A61K36/48A61K36/51A61K36/537A61K36/60A61K36/748A61K36/82A61K36/87A61K36/8888A61K45/06A61P35/00A61P35/02A61K2300/00
Inventor 向飞杜志博冯艺虹谭春霞杨衍秋彭韪
Owner 中山万远新药研发有限公司