A database system for measuring human phenotypes in 3D
A database and phenotype technology, applied in the field of database systems for 3D measurement of human phenotypes, can solve problems such as errors and obstacles, and achieve the effects of avoiding inaccuracy, low requirements for cooperation, and benefiting medical analysis
Active Publication Date: 2022-02-01
DUKE KUNSHAN UNIVERSITY +1
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Problems solved by technology
However, the measurement results of human phenotype still vary from person to person, and there are errors
Moreover, China currently lacks a measurement phenotype database system that can target Chinese people, which makes Chinese people's road to human phenome medical research, or the further development of clinical genetics, there are many obstacles
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experiment example
[0099] The subject was an 8-month-old female infant
[0100] Step 1: The baby girl stands at the specified position in the camera group collection device, facing the specified camera, and collects data instantly without flash or stimulation.
[0101] Step 2: The system quickly obtains various phenotype data of the baby girl through measurement data calculation, and quickly detects, analyzes and compares, and screens out abnormal phenotypes. Among them, if the head circumference value and eye distance deviate from the normal value, the system will issue a high warning, which will be displayed in the test report.
[0102] In the third step, based on the test report, the child health physician recommends that the parents be referred to a genetic specialist.
[0103] It can be seen that, according to the database system of the present invention, the human body phenotype coefficient of the testee can be measured, and compared with the human body phenotype data in the database, it ...
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The present invention proposes a database system for 3D measurement of human phenotypes, including: a data collection module for instantly collecting RGBD image data of the subject's human head from multiple angles; a model restoration module for splicing multi-angle RGBD images data and reconstruct the three-dimensional model of the human head; the feature recognition module is used to identify the characteristic mark points on the three-dimensional model of the human head; the phenotype calculation module is used to calculate the human body phenotype coefficient; The human phenotype coefficient of the testee is stored in the corresponding personal file, and the Chinese database is established; the database analysis module compares the human phenotype coefficient of the testee with the Chinese database, and calculates the proportional position of the testee in the overall data ranking of the Chinese people ; The triage suggestion module provides suggestions according to the outliers compared and screened out by the input analysis module. The invention can measure the phenotype of the human body accurately and professionally and standardizedly, establish a database, and analyze the tested subjects.
Description
technical field [0001] The invention relates to the technical field of 3D scanning and the field of image processing, in particular to a database system for 3D measuring human phenotype. Background technique [0002] The human phenome is a collection of all biological traits composed of morphological characteristics, functions, behaviors, and biological molecules from embryonic development to birth, growth, aging, and death. It is a combination of genes and the environment and the interaction between the two all biological traits. In 2008, the Human Phenotype Ontology (HPO) was launched at the Charité Medical School in Berlin, Germany, and is dedicated to providing a conceptual and semantic tool for large-scale computational analysis of the human phenome. The "Human Phenotype Project" is regarded as another strategic commanding height after the "Human Genome Project", which will provide a new breakthrough and a new paradigm for biomedical research, comprehensively interpret...
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IPC IPC(8): G16H50/70G06F16/583G06T17/00G06V40/16
CPCG16H50/70G06F16/583G06T17/00G06V40/171
Inventor 詹国栋李明邹小兵潘悦然蔡昆京程铭
Owner DUKE KUNSHAN UNIVERSITY