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A self-healing hydrogel synthesized by autocatalysis, a preparation method of the gel precursor thereof, and a synthesis method of the hydrogel

A self-healing and hydrogel technology, which can be applied to other methods of inserting foreign genetic materials, recombinant DNA technology, etc., can solve problems such as reducing the biocompatibility of gels, and achieve good self-repairing ability and good biocompatibility. , the effect of improving biocompatibility

Active Publication Date: 2022-03-25
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing in situ forming hydrogel systems require ultraviolet light irradiation or the addition of catalysts, which reduces the biocompatibility of the gel to some extent.

Method used

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  • A self-healing hydrogel synthesized by autocatalysis, a preparation method of the gel precursor thereof, and a synthesis method of the hydrogel
  • A self-healing hydrogel synthesized by autocatalysis, a preparation method of the gel precursor thereof, and a synthesis method of the hydrogel
  • A self-healing hydrogel synthesized by autocatalysis, a preparation method of the gel precursor thereof, and a synthesis method of the hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A self-healing hydrogel synthesized by autocatalysis takes polyethylene glycol dicyanoacetate and polyamine polyaldehyde as precursors, and the active methylene provided by polyethylene glycol dicyanoacetate is combined with The aldehyde group provided by the polyamine-based polyaldehyde and the catalyst tertiary amine form a self-healing hydrogel in situ via a Knoevenagel condensation reaction.

[0054] The present invention also includes a method for preparing a gel precursor for preparing the above-mentioned self-healing hydrogel synthesized by autocatalysis, comprising the following steps:

[0055] (1), the preparation of polyethylene glycol dicyanoacetate:

[0056] Weigh 5 g of dihydroxy polyethylene glycol and 1.08 g of cyanoacetic acid, dissolve in 80 mL of toluene, then add 2-3 drops of concentrated sulfuric acid, and reflux at 100 ° C for 24 h to obtain a pale yellow liquid; the obtained liquid is concentrated and dissolved in dichloromethane , washed with satur...

Embodiment 2

[0073] The same parts of this example and Example 1 will not be repeated, and the difference is that: PEGDCA and polyamine polyaldehyde are respectively dissolved in deionized water, and after uniformly dissolving, a solution with a concentration of 20% is obtained respectively, and the solution is quickly mixed uniformly, Allow to stand to obtain a self-healing hydrogel.

Embodiment 3

[0075] The same parts of this embodiment and embodiment 1 will not be repeated, but the difference is that they are respectively dissolved in deionized water, and after uniform dissolution, a solution with a concentration of 10% is obtained, which is quickly mixed evenly, and left to stand to obtain self-repairing water. gel.

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Abstract

The invention relates to the technical field of hydrogel preparation, in particular to a method for preparing a self-repairing hydrogel synthesized by self-catalysis and a gel precursor thereof, and a method for synthesizing the hydrogel. Using polyethylene glycol dicyanoacetate and polyamine-based polyaldehyde as precursors, through the active methylene provided by polyethylene glycol dicyanoacetate and the aldehyde group and catalyst provided by polyamine-based polyaldehyde Amines, form self-healing hydrogels in situ via Knoevenagel condensation reactions. Since the gel precursor provides a tertiary amine as a catalyst for the Knoevenagel condensation reaction, the preparation of the hydrogel does not require additional catalysts or ultraviolet light, and has self-catalytic properties, which can greatly improve the biocompatibility of the hydrogel , since no additional catalyst is needed, it is formed by dynamic C=C bond cross-linking in a self-catalyzed environment, so the obtained hydrogel has good self-healing ability, and can quickly self-heal after being damaged by the outside world.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a method for preparing a self-healing hydrogel synthesized by autocatalysis and a gel precursor thereof, and a method for synthesizing the hydrogel. Background technique [0002] Hydrogels are a class of cross-linked polymers with a three-dimensional network structure with a large number of hydrophilic groups or domains. These networks have high affinity for water and have many characteristics similar to extracellular matrix, and in recent years, due to their good biocompatibility, they have been widely studied and applied in various biomedical applications (tissue engineering, drug delivery, wound healing, cell culture, etc.), flexible electronics, bionics. [0003] In situ formed hydrogels exhibit low viscosity in the sol state and can fill defects of any shape, allowing homogeneous incorporation of therapeutic molecules and / or cells without surgical intervention,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02C08J3/075C12N15/87C08L87/00
CPCC08G81/025C08J3/075C12N15/87C08J2387/00
Inventor 高利龙焦彩彩
Owner QINGDAO UNIV
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