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Composition for treating striae gravidarum and blemish and preparation method of composition

A composition and technology for stretch marks, which can be used in cosmetic preparations, skin care preparations, pharmaceutical formulations, etc., can solve the problems of low effective rate and slow effect, achieve shortened length and width, high efficiency, and facilitate repair Effect

Inactive Publication Date: 2020-06-02
SHANDONG XINRUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned patents are used to treat stretch marks, and have the defects of slow effect and low efficiency

Method used

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  • Composition for treating striae gravidarum and blemish and preparation method of composition
  • Composition for treating striae gravidarum and blemish and preparation method of composition
  • Composition for treating striae gravidarum and blemish and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Stem Cell Culture Supernatant

[0037] Take the neonatal umbilical cord donated by the hospital, sterilize it twice with 75% alcohol in the ultra-clean workbench, put it in a petri dish, use tweezers to peel off the Fahrenheit jelly tissue, and cut it to 0.5mm with scissors 2 sized nubs. Transfer the shredded Wahrenheit jelly tissue to a culture bottle, add UltraCULTURE medium containing plasma substitute for culture, and observe with a microscope every day. When the grown stem cells covered 80% of the bottom of the bottle, they were passaged. After passage, the growth rate of the cells was accelerated, and they were passed to one generation every 2-3 days. When the stem cells were passed to the P3 and P4 generations, the culture supernatant was collected for later use. whichever is 4×10 6 Flow cytometry was performed to verify that they were mesenchymal stem cells. The high expression of CD105, CD73, and CD90 and the low expression of CD34 an...

Embodiment 2

[0039] Example 2 A composition for the treatment of stretch marks and scars

[0040] The composition is a spray;

[0041] The composition includes active ingredients and auxiliary agents;

[0042] The active ingredients include arabinogalactan, zinc gluconate, copper gluconate, sodium ascorbate and stem cell culture supernatant; the auxiliary agent is distilled water.

[0043]The composition, calculated by mass percentage, includes the following components:

[0044] 2% arabinogalactan, 2% zinc gluconate, 2% copper gluconate, 0.5% sodium ascorbate, 20% stem cell culture supernatant, and distilled water make up 100%.

[0045] The stem cell culture supernatant is UltraCULTURE medium containing various cytokines and chemokines, wherein the concentration of EGF factor is 70ng / ml, the concentration of FGF factor is 90ng / ml, the concentration of VEGF factor is 80ng / ml, IL- The factor 10 concentration was 85 ng / ml.

[0046] The above-mentioned components are formulated into a spra...

Embodiment 3

[0048] The composition prepared in Example 2 was used for the efficacy test, and compared with the mesenchymal stem cell culture supernatant containing only 20%, the specific scheme is as follows:

[0049] 100 postpartum women were randomly selected and divided into two groups, one group used the composition prepared above, and the other group used only 20% mesenchymal stem cell culture supernatant (the remaining 80% was distilled water). If they have symmetrical or similar stretch marks on their thighs or abdomen, choose one of their thighs, spray the spray there, and massage gently in a clockwise direction, twice a day. The other leg served as a control group. Each thigh was evaluated every other week by clinical examination and instrumental measurements. The women also applied the spray to all areas concerned with stretch marks to get a full assessment of the results.

[0050] The effect is evaluated from the following aspects: outline of stretch marks, color of stretch m...

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Abstract

The invention provides a composition for treating striae gravidarum and blemish. The composition comprises the following active components of arabinogalactan, zinc gluconate, copper gluconate, sodiumascorbate and a stem cell culturing supernatant. According to the prepared composition for repairing striae gravidarum and blemish, the taking-effect time that single mesenchymal stem cells are used for culturing the supernatant is shortened, and quick repair of skin blemish is promoted. In addition, several active components are added, so that repair of the striae gravidarum is facilitated. Afterthe composition is continuously used for 5 weeks, striae gravidarum of 60-68% or more of an examinee can be obviously improved, and after the composition is continuously used for 8 weeks, striae gravidarum of 92-98% or more of the examinee can be obviously improved, length and width of the striae gravidarum are obviously shortened, and the moisturizing capacity of round skin is improved. Only composition containing the supernatant cultured with the mesenchymal stem cells is used for experiment, and after continuous use lasts for 8 weeks, striae gravidarum of only 54-60% of the examinee is obviously improved.

Description

technical field [0001] The invention relates to a composition and a preparation method for treating stretch marks and scars, and belongs to the technical field of biology and new medicine. Background technique [0002] Stretch marks are fine lines or bands of skin that appear after excessive skin expansion (weight gain) and hormonal changes. These skin lines or bands are parallel and elongated, 5-15 cm in length and 0.2-1 cm in width. They can be thin and barely noticeable, but they sometimes form small dimples that fold the skin. Stretch marks can vary from light pink to purple in the beginning (immature or inflammatory stretch marks), and they change color over time and become pearly white (mature stretch marks). Then they become less visible, but the scars remain. Pregnancy-related stretch marks occur on the front surface or abdomen, but some also appear on the breasts, thighs, and buttocks. [0003] Stretch marks are caused by rapid or sudden stretching of the skin, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/73A61K8/67A61K8/365A61Q19/00A61Q19/08
CPCA61K8/99A61K8/676A61K8/365A61K8/73A61Q19/00A61Q19/08
Inventor 刘明录刘媛媛张传鹏王立新王成斌金海锋李希鹏许淼马洪华
Owner SHANDONG XINRUI BIOTECH CO LTD
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