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Medical titanium-based composite rod with osteoinductive and osteopromotive active outer layer degradable and preparation method thereof
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An osteoinductive and composite rod technology, applied in the direction of femoral head, medical science, shoulder joint, etc., can solve the problems of fast degradation of magnesium alloy, low mechanical strength, and loss of mechanical support of materials
Inactive Publication Date: 2021-08-20
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Titanium alloy is widely used because of its good biocompatibility, but titanium alloy can only play a role of connection and support, and has no effect on promoting the growth of new bone at the implanted site, which affects the therapeutic effect
[0003] Magnesium alloys and zinc alloys can be completely degraded in the human body. Magnesium alloys have a fast degradation rate and severe pitting corrosion, which makes the material lose its mechanical support prematurely and cannot meet the needs of patients.
Zinc alloy can effectively reduce its degradation rate, but there are problems such as low mechanical strength, which limits its application in implant materials. None of the above materials can promote the growth of new bone, resulting in a longer recovery period for patients and causing severe damage to patients. Great pain, unsatisfactory treatment effect
[0004] The existing implant materials achieve the effect of inducing bone formation by setting an osteoinductive coating. However, at this time, the growth of new bone is slow, and the strength of the newly grown new bone is weak, the load-bearing capacity is poor, and it is easy to crack. incapable of functioning normally
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Embodiment 1
[0050] like Figures 1 to 7 Shown: a degradable medical titanium-based composite rod with osteoinductive and bone-promoting active outer layers, with a titanium alloy rod layer 1, a zinc alloy layer 2, and a magnesium alloy layer 3 in sequence from the inside to the outside; the titanium alloy rod Layer 1 has a circular cross-section perpendicular to the length of the bar. Specifically, the magnesium alloy layer 3 includes a first arc portion 3-2 and a second arc portion 3-3, and the first arc portion 3-2 and the second arc portion 3-3 have Symmetry, by setting the magnesium alloy layer 3 as two arc-shaped parts, it is convenient for the processing and forming of the magnesium alloy layer 3, and the middle position of the first arc-shaped part 3-2 and the second arc-shaped part 3-3 is provided with an inwardly extending The dovetail rib 3-1, the inner circumference of the first arc portion 3-2 and the second arc portion 3-3 are provided with arc grooves 3-4, and the arc groov...
Embodiment 2
[0057] Embodiment 2 provides a medical titanium-based composite rod with an osteoinductive and osteopromotive active outer layer that can be degraded. The difference from Embodiment 1 is that the magnesium alloy layer 3 is integrally formed. The structure is as follows: Figures 8 to 10 shown. Those skilled in the art can also set up other similar replacement structures as required.
Embodiment 3
[0059] The preparation method of the degradable medical titanium-based composite rod with osteoinductive and bone-promoting active outer layer in Example 1 comprises the following steps:
[0060] (1) Take the titanium alloy rod and heat it to 620°C, then cast the zinc alloy melt at 530°C externally to obtain a metallurgically bonded titanium-zinc bimetallic rod; the chemical composition of the titanium alloy rod is: Si 3.5% by mass percentage , Zr 6.5%, Nd1.5%, Fe 2%, Mo 0.5%, Sr 0.5%, Se 0.5%, the balance is Ti; the chemical composition of zinc alloy is calculated by mass percentage: Ca5%, Mn 3%, Mg 0.85 %, K 1.0%, Ag 0.55%, La 0.6%, Se 0.6%, Sr 0.75%, the balance is Zn;
[0061] (2) Machining a dovetail groove 2-2 on the titanium-zinc bimetallic bar in the above step (1);
[0062] (3) A fan-shaped filling groove 2-3 is processed on the zinc alloy layer of the titanium-zinc bimetallic rod in the above step (2), and the bone-promoting active substance 4 is injected into the f...
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Abstract
The invention discloses a medical titanium-based composite bar with degradable outer layers with osteoinductive and bone-promoting activities. A titanium alloy bar layer, a zinc alloy layer and a magnesium alloy layer are arranged in sequence from the inside to the outside; the magnesium alloy layer is provided with Inwardly extending dovetail rib, the zinc alloy layer is provided with a dovetail groove matched with the dovetail rib, the bottom of the dovetail groove extends to the titanium alloy bar layer, and the magnesium alloy layer is provided with an arc-shaped groove in the circumferential direction, and the arc-shaped groove The inside is filled with osteoinductive active substances; the fan-shaped filling grooves are arranged in the radial direction in the zinc alloy layer, and the bone-inducing active substances are filled in the fan-shaped filling grooves. After the above bar is implanted into the human body, the magnesium alloy layer is rapidly absorbed, the osteoinductive active substance induces bone formation, the zinc alloy layer and the bone promoting active substance promote bone growth and strengthen the bone strength, and the titanium alloy bar remains in the body. The present invention also provides a method for preparing the above-mentioned bar, which is easy to operate and convenient for industrialized production.
Description
technical field [0001] The invention relates to the technical field of new medical materials, in particular to a degradable medical titanium-based composite rod with osteoinductive and osteopromotive active outer layers and a preparation method thereof. Background technique [0002] Key parts such as the femur and humerus of the human body need to have good load-bearing capacity. When implanting medical metal materials, they need to bear specific loads in the body and retain them permanently or semi-permanently. This requires the implanted materials to have a certain strength. And has better stability. The existing commonly used rigid materials are mostly stainless steel or titanium alloy. Among them, stainless steel contains chromium, nickel and other components, and some stainless steels also contain cobalt. During the indwelling process of the human body, stainless steel materials will diffuse chromium, nickel and other elements that are toxic to the human body into huma...
Claims
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