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Absorbable anti-adhesion dressing and preparation method thereof

An anti-adhesion, mixed-liquid technology, applied in dressings, absorbent pads, adhesive dressings, etc., can solve problems such as exogenous infection, adhesion of clothing and dust, delayed wound healing, etc., and achieve good degradability and mechanical properties. , easy to obtain, the effect of promoting one-way absorption

Active Publication Date: 2020-06-05
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings such as absorbent cotton gauze, cotton pads, and Vaseline gauze have a net-like weaving structure. Although they are cheap, the manufacturing process is relatively simple, the source of raw materials is wide, the texture is soft, and they have strong absorption capacity, they can prevent the accumulation of exudate on the wound surface. It also has a certain degree of protective effect on wound healing, but it cannot keep the wound moist, which will delay wound healing, poor barrier effect after dressing penetration, easy to cause exogenous infection, poor hemostatic effect, and wound granulation tissue is easy to grow into the mesh of the dressing In the eyes, when the dressing is changed, it is easy to adhere to the wound surface, damage the new granulation tissue and cause pain, and sometimes the exudate will leak through the dressing, adhere to clothing and dust, and cause wound infection

Method used

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  • Absorbable anti-adhesion dressing and preparation method thereof
  • Absorbable anti-adhesion dressing and preparation method thereof
  • Absorbable anti-adhesion dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]An absorbable anti-adhesion dressing, the absorbable anti-adhesion dressing is composed of a hydrophobic layer, a hydrophilic layer and a protective layer from the side close to the skin; the hydrophobic layer is polycaprolactone / chitosan loaded with microspheres Porous sugar film, the microspheres are made of sodium alginate, Chinese medicine extract, epidermal growth factor, chitosan and lecithin, and the Chinese medicine extract is the extract of Panax notoginseng, Artemisia argyi and Centella asiatica; The material of the hydrophilic layer is one or more of hyaluronic acid, gelatin, sodium alginate or keratin; the protective layer is composed of eggshell membrane and modified polyurethane film, and the modified polyurethane film is Sodium carboxymethyl cellulose modified polyurethane film.

[0032] The eggshell membrane is to knock out the egg white and yolk of the egg, peel off the inner membrane, wash the remaining egg white liquid on the membrane, and soak it in a...

Embodiment 2

[0042] An absorbable anti-adhesion dressing, the absorbable anti-adhesion dressing is composed of a hydrophobic layer, a hydrophilic layer and a protective layer from the side close to the skin; the hydrophobic layer is polycaprolactone / chitosan loaded with microspheres Porous sugar film, the microspheres are made of sodium alginate, Chinese medicine extract, epidermal growth factor, chitosan and lecithin, and the Chinese medicine extract is the extract of Panax notoginseng, Artemisia argyi and Centella asiatica; The material of the hydrophilic layer is one or more of hyaluronic acid, gelatin, sodium alginate or keratin; the protective layer is composed of eggshell membrane and modified polyurethane film, and the modified polyurethane film is Sodium carboxymethyl cellulose modified polyurethane film.

[0043] The eggshell membrane is after the egg white and egg yolk are knocked out, the inner membrane is peeled off, the egg white liquid remaining on the membrane is cleaned, an...

Embodiment 3

[0053] An absorbable anti-adhesion dressing, the absorbable anti-adhesion dressing is composed of a hydrophobic layer, a hydrophilic layer and a protective layer from the side close to the skin; the hydrophobic layer is polycaprolactone / chitosan loaded with microspheres Porous sugar film, the microspheres are made of sodium alginate, Chinese medicine extract, epidermal growth factor, chitosan and lecithin, and the Chinese medicine extract is the extract of Panax notoginseng, Artemisia argyi and Centella asiatica; The material of the hydrophilic layer is one or more of hyaluronic acid, gelatin, sodium alginate or keratin; the protective layer is composed of eggshell membrane and modified polyurethane film, and the modified polyurethane film is Sodium carboxymethyl cellulose modified polyurethane film.

[0054] The eggshell membrane is after the egg white and egg yolk are knocked out, the inner membrane is peeled off, the egg white liquid remaining on the membrane is cleaned, an...

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Abstract

The invention provides an absorbable anti-adhesion dressing. The absorbable anti-adhesion dressing sequentially comprises a hydrophobic layer, a hydrophilic layer and a protective layer from the sideclose to the skin, wherein the hydrophobic layer is a microsphere-loaded polycaprolactone / chitosan porous film; the hydrophilic layer is made of one or more selected from the group consisting of hyaluronic acid, gelatin, sodium alginate and keratin; and the protective layer is prepared by compounding an egg shell film and a modified polyurethane film. The invention also provides a preparation method for the absorbable anti-adhesion dressing. The absorbable anti-adhesion dressing prepared by using the preparation method provided by the invention can be degraded and absorbed, does not to be frequently replaced, maintains a moist environment beneficial to wound repair, has excellent mechanical properties and high antibacterial effect, can promote one-way absorption of a medicine, is improvedin utilization rate, does not generate the problem of wound adhesion when being replaced, and prevents secondary injury.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to an absorbable anti-adhesion dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body and has the functions of retaining moisture in the body, preventing excessive heat dissipation, ventilating and preventing bacterial invasion. In daily life, wounds, abrasions, skin ulcers, burns and other wounds inevitably appear on the skin surface of the human body. If these wounds are not treated effectively, they may lead to a wider range of injuries, such as: infection, loss of body fluids, and various complications disease etc. [0003] If only a superficial layer or a small area of ​​the skin is damaged, the new skin will regenerate itself, but if it is severely traumatized, the skin cannot repair itself, and medical dressings are usually attached to promote wound healing. Traditional dressings such as absorbent cotton g...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61L15/26A61L15/28A61L15/32A61L15/40A61L15/42A61L15/44A61L15/46A61L15/62
CPCA61F13/0206A61F13/0289A61L15/26A61L15/28A61L15/32A61L15/325A61L15/40A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/30A61L2300/404A61L2300/412A61L2300/602A61L2300/622C08L5/08C08L5/04C08L89/00C08L75/04
Inventor 张正男段书霞韩涵付迎坤孙海鹏石沛龙崔彬彬邵蕊娜韩修恒田崇周静郝明严子跃佘开江姬鹏远王喜卫段晓堂
Owner HENAN YADU IND
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