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Organic acid compound and preparation method and application thereof

A technology of compounds, organic acids, applied in the field of natural medicinal chemistry

Active Publication Date: 2020-06-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on the chemical constituents and pharmacological effects of Thuja taihang

Method used

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  • Organic acid compound and preparation method and application thereof
  • Organic acid compound and preparation method and application thereof
  • Organic acid compound and preparation method and application thereof

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Embodiment Construction

[0034] The following examples are intended to illustrate the present invention rather than to further limit the present invention, and the present invention can be implemented according to any mode described in the summary of the present invention.

[0035] The preparation embodiment of formula (I) compound of the present invention:

[0036] compound preparation

[0037] Taihang Thuja medicinal material 50 kg, provided by Hebei Yunjing Biotechnology Co., Ltd.

[0038] (1) Medicinal material extraction: Taihang Thuja shaving-like medicinal material 5kg, add pure water at a volume ratio of 1:10, heat and reflux at 90°C for 1.5 hours, filter while hot, repeat the extraction once, filter while hot, and combine 2 filtrate concentrate

[0039] (2) Use the reverse phase preparation column (C18YE packing, 60um) to roughly separate the concentrated solution obtained in step (1), and wash it with ethanol-water at a volume ratio of 10:90, 60:40, 50:50, and 90:10 in sequence Take off, ...

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Abstract

The invention relates to a preparation method and application of a novel organic acid compound in Thuja sutchuenensis, and researches on GPR35 activity show that the compound is a GPR35 receptor stimulant and can be used in medicines for preventing and treating related diseases such as hypertension, asthma, pain, inflammation, tumors and the like.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and relates to a new compound Taihang thujic acid A, its preparation method and its related application as a GRR35 agonist Background technique [0002] Taihang Thuja is a plant of the genus Arborvitae of the Cupressaceae family, mainly distributed in the Taihang Mountains. Although it is not classified as Thuja genus, its growth environment is very similar to that of Thuja botanica, both of which grow on cliffs at higher altitudes. The unique geographical environment and climate make its appearance and internal composition very different from ordinary arborvitae. Since thuja is an endangered plant, it is relatively difficult to obtain, but it is recorded in the Compendium of Materia Medica and has special pharmacological effects. Therefore, research on Taihang Thuja, which is very similar to Thuja thuja, is expected to find pharmacological molecules similar to Thuja thuja. At presen...

Claims

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Application Information

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IPC IPC(8): C07C65/01C07C51/47A61K31/192A61P3/10A61P9/12A61P9/04A61P9/10A61P11/06A61P3/00A61P29/00A61P35/00
CPCA61P3/00A61P3/10A61P9/04A61P9/10A61P9/12A61P11/06A61P29/00A61P35/00C07C51/47C07C65/01
Inventor 梁鑫淼魏红丽金红利刘艳芳侯滔王纪霞钮蕊
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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