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A traditional Chinese medicine composition for inhibiting the formation of dental plaque, its preparation method and its application

A composition and a technology for dental plaque, applied in the field of medicine, can solve the problems of reducing the comfort and acceptance of a patient's experience, and achieve the effects of inhibiting growth and adhesion, avoiding dental plaque, and enhancing the effects of acrid and cooling on the skin.

Active Publication Date: 2022-03-29
广东君道营养科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the experience comfort and acceptance of patients is reduced due to the adverse effects of some preparations such as corrosiveness, pungent odor and tooth staining

Method used

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  • A traditional Chinese medicine composition for inhibiting the formation of dental plaque, its preparation method and its application
  • A traditional Chinese medicine composition for inhibiting the formation of dental plaque, its preparation method and its application
  • A traditional Chinese medicine composition for inhibiting the formation of dental plaque, its preparation method and its application

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preparation example Construction

[0028] In the second aspect, the embodiment of the present invention provides a preparation method of the above-mentioned traditional Chinese medicine composition for inhibiting dental plaque formation, comprising: mixing Houttuynia cordata, dandelion, peppermint, honeysuckle and licorice in proportion, adding a solvent to extract, filtering, and The obtained filtrate is concentrated to a thick paste, that is, too.

[0029] Further, the preparation method includes the following steps: respectively fully drying Houttuynia cordata, dandelion, peppermint, honeysuckle and licorice, mechanically pulverizing and superfine pulverizing, putting them into water or ethanol, extracting, concentrating and suction filtering.

[0030] Further, the temperature of leaching is 40-70° C., and the time is 30-60 minutes.

[0031] Further, the concentrating conditions are as follows: centrifuging the extract, collecting the supernatant and concentrating under reduced pressure at 50-70°C to 35-45% ...

Embodiment 1

[0039] Screening of antibacterial effect of common traditional Chinese medicine on Streptococcus mutans:

[0040]Streptococcus mutans made 10 4 / mL bacterial suspension, with tetracycline as the positive control and deionized water as the negative control, take 250 μL of the concentrated clear filtrate of various plant material water extracts and alcohol extracts, add it to the bacterial suspension, and place it on a constant temperature shaker at 37°C Cultivate for 12 hours, serially dilute the mixed bacterial solution and smear the plate, cultivate in a biochemical incubator at 37°C for 24 hours, count the colonies, calculate the bacteriostatic rate, and the bacteriostatic rate=(the number of colonies in the experimental group-the number of colonies in the negative control group) / the number of colonies in the control group, Using SPSS to carry out one-way analysis of variance and multiple comparison analysis of differences between groups, it was found that except for chrysan...

Embodiment 2

[0062] A traditional Chinese medicine composition for inhibiting the formation of dental plaque, comprising the following components in parts by weight: 5 parts of Houttuynia cordata, 15 parts of dandelion, 20 parts of mint, 25 parts of honeysuckle and 15 parts of licorice.

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Abstract

The invention discloses a traditional Chinese medicine composition for inhibiting the formation of dental plaque, a preparation method and its application. According to the antibacterial activity of the extracted liquid, five medicinal and edible resources such as houttuynia cordata, dandelion, mint, honeysuckle and licorice are selected, Then, it is optimized and combined with reference to the compatibility rules of traditional Chinese medicines to form a compound with better taste. The working principle of the present invention is to use phytochemical extracts to adjust the dynamic balance of the oral flora, and to prevent the formation of dental plaque by inhibiting the growth and adhesion of pathogenic bacteria such as Streptococcus mutans, thereby alleviating periodontitis and halitosis. The population trial test shows that the composition can effectively inhibit the formation of dental plaque, and the five components have a synergistic effect. The composition can be developed into products such as mouthwash, oral spray and solid drink.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for inhibiting the formation of dental plaque, a preparation method and an application thereof. Background technique [0002] Dental plaque is a soft and unmineralized bacterial organism formed by a large number of bacteria that settle on the tooth surface, between teeth or on the surface of dentures (dentures, restorations), plus exfoliated oral epithelial cells and food residues. The film, which is very adhesive, is difficult to remove by rinsing and brushing. The growth, reproduction, and acid production of bacteria in the plaque demineralize the enamel, which is a common cause of periodontal disease, dental caries and other dental diseases. In addition, plaque can calcify into tartar, which can lead to bad breath. Since bacterial growth is continuous, the key to plaque control is the frequent suppression of harmful oral bacteria, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61P1/02A61P31/04A61K8/9789A61Q11/00A61Q17/00A23L33/105
CPCA61K36/78A61K36/288A61K36/534A61K36/355A61K36/484A61P1/02A61P31/04A61K8/9789A61Q11/00A61Q17/005A23L33/105A61K2236/331A61K2236/33A61K2236/51A61K2236/53A23V2002/00A61K2300/00A23V2250/21A23V2200/312
Inventor 郭红辉方鹏宇龙妙茹
Owner 广东君道营养科技有限公司
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