Method and device for monitoring and adjusting regional citrate anticoagulation

Abstract

The invention provides a method and device for monitoring and adjusting regional citrate anticoagulation. The method comprises the steps of: constructing a citrate monitoring and adjusting model basedon a citrate dosage pumping value of a sample, a filtered blood gas free calcium ion influence parameter value, and a filtered blood gas free calcium ion concentration; inputting a to-be-adjusted citrate dosage pumping value of a target patient and a configured value of the filtered blood gas free calcium ion influence parameter into the citrate monitoring and adjusting model to obtain a filteredblood gas free calcium ion predicted concentration of the target patient; querying a mapping relationship between the filtered blood gas free calcium ion concentration and a citrate dosage pumping value adjustment strategy, and acquiring a citrate dosage value adjustment strategy mapped by the filtered blood gas free calcium ion predicted concentration; and adjusting the to-be-adjusted citrate dosage pumping value according to the citrate dosage value adjustment strategy to obtain a citrate dosage pumping target value of the target patient, and conducting pumping according to the citric aciddosage pumping target value, thus effectively improving the anticoagulation effect and treatment safety.

Description

technical field [0001] The invention relates to the technical field of substitution therapy, in particular to a method and device for monitoring and adjusting local citrate anticoagulation. Background technique [0002] Continuous Renal Replacement Therapy (CRRT, Continuous Renal Replacement Therapy) is the most commonly used organ replacement support method in the intensive care unit, and it is widely used in critically ill patients. Since severe patients generally have symptoms such as multiple organ failure, surgical trauma, active bleeding, and disseminated intravascular coagulation, it is particularly important to choose a safe, effective, continuous, and stable anticoagulant method. Although heparin anticoagulation has a wide range of applications, good anticoagulation effect, and low price, improper application will increase the risk of bleeding in critically ill patients, and lead to heparin-induced thrombocytopenia (HIT, Heparin-Induced Thrombocytopenia), etc., and ...

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Problems solved by technology

[0003] However, in the local citrate anticoagulant method, after the dose of citrate is pumped, it is necessary to repeatedly monitor the arterial free calcium ion concentration and the total calcium ion concentration in the whole kidney test during the treatment process, and based on The concentration of free calcium ion in the blood gas after the filter adjusts the dose of citrate pumped to avoid excessive citrate caused by excessive anticoagulation, which endangers the life of the patient, and insufficient anticoagulation leads to poor anticoagulant effect

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