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Production technology of difenidol hydrochloride tablets

A technology of diphenidol hydrochloride and a production process, which is applied in the field of medicine, can solve the problems of strong stomach irritation, poor taste, splinter and the like, and achieves the effects of solving poor taste, reducing the manufacturing cost and the complexity of the process.

Inactive Publication Date: 2020-08-14
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to disclose a production process of Diphenidol Hydrochloride Tablets, which is used to overcome the poor taste, strong stomach irritation and stability of the current commercially available Diphenidol Hydrochloride Tablets in the manufacturing process. Poor disadvantages, while avoiding the problems of slivers and unshaped pieces

Method used

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Embodiment Construction

[0027] The present invention will be described in detail below in conjunction with various embodiments, but it should be noted that these embodiments are not limitations of the present invention, and those of ordinary skill in the art can make functional, method, or structural equivalent transformations or replacements based on these embodiments. , all fall within the protection scope of the present invention.

[0028] This embodiment discloses a production process of difenidol hydrochloride tablets, comprising the following steps:

[0029] Step 1: Shred

[0030] Use a universal pulverizer to pulverize potassium hydrogen tartrate to 100 mesh, sieve and weigh, record and make a mark;

[0031] Grind difenidol hydrochloride raw material twice to 120 mesh with a dust-absorbing and pulverizing unit, measure the particle size with a laser particle size analyzer, control the particle size D90 to be less than 75 μm, and make a mark on the weighing record;

[0032] Step 2: Weigh the ...

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Abstract

The invention provides a production technology of difenidol hydrochloride tablets. The production technology comprises the following steps: crushing, ingredient weighing, preparation of a 2% sodium carboxymethyl cellulose aqueous solution, production of wet granules, drying, granulation, total mixing, tableting and coating. Granulation of wet granules with a common adhesive is avoided, so that themanufacturing cost and process complexity can be significantly reduced. Meanwhile, a surface coating layer overcomes the defects that traditional difenidol hydrochloride tablets have poorer taste, strong irritation to the stomach and poorer stability.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a production process of difenidol hydrochloride tablets. Background technique [0002] Diphenidol hydrochloride can improve the blood supply of the vertebral artery, regulate the function of the vestibular system, inhibit the vomiting center, have anti-vertigo and antiemetic effects, and is often used to prevent and treat dizziness, nausea, and vomiting caused by various reasons or diseases, such as driving, boat , Motion sickness when flying. [0003] The Chinese invention patent application with the publication number CN105326803A provides a difenidol hydrochloride tablet for the treatment of motion sickness and a preparation method thereof, wherein every 150 tablets of the diphenidol hydrochloride contain the following components: difenidol hydrochloride 37.5kg of phenidol, 36kg of starch, 6kg of sodium starch glycolate, 17.05kg of ethanol, 9.95kg of purified water; granula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4453A61K47/38A61K47/36A61K47/26A61K47/12A61K47/02A61P1/08
CPCA61K9/2095A61K9/2893A61K9/2054A61K9/2018A61K9/2009A61K9/2013A61K31/4453A61P1/08
Inventor 林凡友孙永喜罗晓倩王美成赵翔
Owner 仁和堂药业有限公司
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