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Composition and preparation method and application in preparing immune adjuvant of compositon

A technology of immune adjuvant and composition, which is applied in the field of microorganisms, can solve the problems of general effect, achieve the effect of reducing the duration, simple preparation, and easy industrial production

Pending Publication Date: 2020-08-14
湖南种太阳医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen that most of the existing microecological immune adjuvants have mediocre effects, and further development of microecological immune agents that non-specifically enhance the body's immune response to vaccines for preventing respiratory tract infections and improve the body's protective ability is still a research hotspot in this field

Method used

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  • Composition and preparation method and application in preparing immune adjuvant of compositon
  • Composition and preparation method and application in preparing immune adjuvant of compositon
  • Composition and preparation method and application in preparing immune adjuvant of compositon

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preparation example Construction

[0045] The preparation method of the composition includes a dry mixing process or a dry-wet composite process:

[0046] Described dry mixing process comprises the following steps:

[0047] Step 1: Put paraphyllan syrup in a high-speed mixer evacuated with medical nitrogen according to a predetermined ratio, then add compound probiotic powder and organic prebiotics in a predetermined ratio, and mix evenly to obtain the first material;

[0048] Step 2: Put solid corn and erythritol into a high-speed mixer according to a predetermined ratio and mix them evenly with the second material to obtain the micro-ecological immune adjuvant

[0049] Described dry-wet composite process comprises the following steps:

[0050] Step 1: Put paraphyllan syrup in a high-speed mixer evacuated with medical nitrogen according to a predetermined ratio, then add compound probiotic powder and organic prebiotics in a predetermined ratio, and mix evenly to obtain the first material;

[0051] Step 2: addi...

Embodiment 1

[0057] Five mixed bacteria of Lactobacillus helveticus R0052, Bifidobacterium lactis Bi07, Lactobacillus rhamnosus GG, Lactobacillus casei L26 and Bifidobacterium longum R0175 were added to the MRS medium with the same inoculation amount for cultivation; the OD600 value was measured every 2 hours , draw the growth curve, the results show that: the OD values ​​measured by the mixed bacteria culture are significantly higher than the single bacteria pure culture, the results are shown in figure 1 . It shows that the advantages of the five strains of probiotics are complementary, and there is no competitive inhibition. The metabolites of one strain may stimulate the growth and metabolism of another strain, resulting in products that cannot be obtained by single-bacteria growth and high viable bacterial counts.

Embodiment 2

[0059] The party is:

[0060] 30 parts of isomaltooligosaccharide, 30 parts of compound probiotic powder (Lactobacillus helveticus R0052, Bifidobacterium lactis Bi07, Lactobacillus rhamnosus GG, Lactobacillus casei L26 and Bifidobacterium longum R0175), 15 parts of euglena, 10 parts of solid corn syrup, 5 parts of erythritol, 5 parts of galacto-oligosaccharide, and 5 parts of fructo-oligosaccharide.

[0061] Preparation methods include:

[0062] 1. Preparation of composite bacterial powder: Inoculate Lactobacillus helveticus R0052, Bifidobacterium lactis Bi07, Lactobacillus rhamnosus GG, Lactobacillus casei L26 and Bifidobacterium longum R0175 into liquid medium containing MRS and culture them anaerobically until The OD600 is not less than 6.5, and the probiotic fermentation broth is obtained. The probiotic fermentation broth is mixed and compounded at a ratio of 3:2:2:1:1, and centrifuged to obtain the composite probiotic bacteria, and then the bacteria are freeze-dried. Fi...

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Abstract

The invention relates to the technical field of microorganisms, and in particular relates to a composition and a preparation method and application in preparing an immune adjuvant of the composition.The combination provided by the present invention comprises prebiotics, probiotics, euglena polysaccharide, solid corn syrup and erythritol. The research results show that the efficiency of vaccines can be enhanced by the joint application of microecological immune adjuvant and respiratory vaccine to help children prevent respiratory tract infections, especially upper respiratory tract infections,the recovery period is shortened, the duration of respiratory symptoms is reduced, and the oral microecological immune adjuvant of the invention is simple to prepare and easy to industrially produce.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a composition, a preparation method thereof and an application in preparation of an immune adjuvant. Background technique [0002] Respiratory tract infection is an infectious disease caused by a variety of microorganisms including bacteria, viruses, mycoplasma, fungi, parasites, etc. Clinical symptoms include: fever, cough, sputum, and dyspnea. Respiratory tract infections are common in children, and antibiotics are often given to treat respiratory infections. However, inappropriate use of antibiotics can lead to various side effects, especially the development of drug resistance in the body. [0003] Prevention of respiratory infections is an important public health challenge. In recent years, more and more people are aware of the importance of using vaccines to prevent respiratory infections, such as pneumonia vaccines, influenza virus split vaccines, etc. The number ...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/09A61K39/145A61K39/095A61K39/25A61K39/165A61K39/10A61P11/00A61P31/16A61P31/14A61P31/04A61P31/22
CPCA61K39/39A61K39/09A61K39/12A61K39/095A61K39/099A61P11/00A61P31/16A61P31/14A61P31/04A61P31/22A61K2039/55588C12N2760/16034C12N2710/16734C12N2760/18434A61K2300/00
Inventor 曹文海陈华纲戴联宇
Owner 湖南种太阳医药科技有限公司
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