Method for establishing and verifying breast cancer prognosis evaluation model based on seven special genes

A technology for prognostic assessment and breast cancer, which is applied in the field of gene technology and biomedicine, can solve the problems of inaccuracy and lack of practicability, and achieve the effect of accurate prognosis

Pending Publication Date: 2020-08-21
辽宁省肿瘤医院
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Problems solved by technology

Currently, several gene biomarkers have been used for prognostic evaluation of breast cancer patients, such as c-Met, Ki67, BRCA1/2, etc., bu

Method used

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  • Method for establishing and verifying breast cancer prognosis evaluation model based on seven special genes
  • Method for establishing and verifying breast cancer prognosis evaluation model based on seven special genes
  • Method for establishing and verifying breast cancer prognosis evaluation model based on seven special genes

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Embodiment

[0027] Example A method for establishing and verifying a breast cancer prognosis assessment model based on 7 special genes.

[0028] (1) Identify genes associated with survival in BRCA development.

[0029] In order to identify new specific biomarkers associated with the prognosis of BRCA patients, univariate analysis was performed on the samples of the test group, followed by multivariate analysis and stepwise regression to select 7 genes with significant prognosis of BRCA patients, see Table 1. And a patient risk assessment model based on these 7 genes was established, namely: risk score = (-0.15110) * LYVE1 +0.4676 * LILRB5 + (-0.2924) * CD209 + 0.1744 * AL049749.1 +0.1990 * AC123595.1+ ( -0.1735)*TMEM190 + (-0.1024)*TUBA3D.

[0030]

[0031] (2) Verify the performance of the risk scoring model in the training set.

[0032] Risk was assessed for each patient using this 7-gene signature model, and the test dataset and the entire dataset were divided into high-risk and ...

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Abstract

The invention relates to the field of gene technology and biomedicine, in particular to a method of for establishing and verifying a breast cancer prognosis evaluation model based on seven special genes. The invention provides the seven genes related to survival in breast cancer development and the method of for establishing and verifying the breast cancer prognosis evaluation model based on the seven special genes. The seven genes related to survival in breast cancer development comprise LYVE1, CD209, TMEM190, TUBA3D, AL049749.1, AC123595.1 and LILRB5. The model can correctly evaluate breastcancer onset risks, accurately predict patient prognosis and guide clinical treatment. Through transcriptome data and clinical data analysis, it is found that prognosis is more accurate through jointprediction via the seven genes, and prognosis evaluation of a patient can lay a foundation for clinical transformation through a nematic diagram.

Description

technical field [0001] The invention relates to the fields of gene technology and biomedicine, in particular to a method for establishing and verifying a breast cancer prognosis evaluation model based on seven special genes. Background technique [0002] Breast cancer (BRCA) is one of the most common invasive cancers in women, accounting for 16% of all female cancers. Studies show that 12% of women worldwide suffer from the condition. The study estimated that there were approximately 20,120 new cases of invasive breast cancer and 40,920 breast cancer deaths among U.S. women in 2018, and breast cancer accounted for 30 percent of newly diagnosed cancers in women. We have seen efforts in breast cancer discovery in the past, but many barriers to treatment remain due to the heterogeneity of breast cancer disease at the molecular and genetic level (multiple subtypes). Mammography is the most commonly used breast cancer screening method, but problems such as overdiagnosis and ove...

Claims

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Application Information

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IPC IPC(8): G16H50/30
CPCG16H50/30Y02A90/10
Inventor 王哲吴锋
Owner 辽宁省肿瘤医院
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