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Pharmaceutical compositions

A composition and drug technology, applied in the direction of nano-drugs, pharmaceutical formulations, nano-technology, etc., can solve the problems of treatment costs and increased adverse side effects

Active Publication Date: 2020-08-25
CIPLA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] While TDF and TAF exhibit desirable activity, treatment costs and potential for adverse side effects increase as the amount of drug required increases

Method used

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  • Pharmaceutical compositions
  • Pharmaceutical compositions
  • Pharmaceutical compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0087] Example 2-(((((R)-1-(6-amino-9H-purin-9-yl)propane-2-yl)oxy)methyl)(phenoxy)phosphoryl)oxy ) methyl pivalate fumarate tablet

[0088]

Embodiment 3

[0089] Example 3-(((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)oxy ) methyl pivalate fumarate tablet

[0090]

Embodiment 4

[0091] Example 4-(((((R)-1-(6-amino-9H-purin-9-yl)propane-2-yl)oxy)methyl)(phenoxy)phosphoryl)oxy ) methyl pivalate fumarate dispersible tablets

[0092]

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Abstract

The invention relates to pharmaceutical compositions comprising ((((((R)-1-(6- amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)oxy)methyl pivalate or a pharmaceutically acceptable derivative thereof, optionally with an additional agent, methods of making them, and their use in medicine.

Description

Technical field: [0001] The present invention relates to a pharmaceutical composition comprising (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)( phenoxy)phosphoryl)oxy)methyl pivalate or a pharmaceutically acceptable derivative thereof. The present invention also provides its preparation method and the use of the composition for preventing, treating or preventing diseases caused by viruses (especially acquired immunodeficiency syndrome, HIV infection, hepatitis B infection or hepatitis C infection). [0002] Background of the invention: [0003] Human immunodeficiency virus type 1 (HIV-1) infection is a life-threatening serious disease of major public health significance, with approximately 36.7 million people infected worldwide (United Nations Program on AIDS (UNAIDS). Global Report: UNAIDS About Report on the Global AIDS Epidemic, 2016). [0004] Acquired immunodeficiency syndrome (AIDS) results in a gradual breakdown of the body's immune system and progressive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/16A61K31/675A61P31/18A61P31/20
CPCA61K9/1623A61K9/2018A61K9/2054A61K31/675A61P31/20A61P31/18A61P31/22A61K45/06B82Y5/00
Inventor G·马尔霍特拉K·乔希J·哥萨尔卡尔A·达罗伊S·阿格拉瓦尔
Owner CIPLA LTD