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A kind of belladonna extract and belladonna capsule compound preparation

The technology of belladonna extract and compound preparation, which is applied in the field of medicine, can solve the problems of low purity, incomplete impurity removal, high chlorophyll content in belladonna extract, etc., and achieves the effects of preventing moisture absorption and high clinical application value.

Active Publication Date: 2022-01-18
HONGMEI PHARMA CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned method gained belladonna extract chlorophyll content is more, and purity is lower, impurity removal is not thorough

Method used

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  • A kind of belladonna extract and belladonna capsule compound preparation
  • A kind of belladonna extract and belladonna capsule compound preparation
  • A kind of belladonna extract and belladonna capsule compound preparation

Examples

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Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 belladonna extract

[0069] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0070] (1) 1000g belladonna is roughly crushed into coarse powder (particle size is about 2.0mm), and the coarse powder is added to the ethanol solution containing 0.1% sulfuric acid (percolation extraction solvent, about 3000ml, the same below), at 600W Ultrasonic mixing for 4h;

[0071] (2) The belladonna coarse powder after the ultrasonic treatment is percolated (with the ethanol solution containing 0.1% sulfuric acid in step 1 as the percolation extraction solvent, and the insufficient part is filled), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0072] (3) Use filter paper to suction filter...

Embodiment 2

[0078] Embodiment 2 belladonna extract

[0079] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0080] (1) Coarsely crush 1000 g of belladonna into a coarse powder (particle size is about 2.0 mm), add the coarse powder to an ethanol solution containing 0.1% hydrochloric acid (percolation extraction solvent), and ultrasonically mix at 600W for 4 hours;

[0081] (2) The belladonna coarse powder after ultrasonic treatment is percolated (with the ethanol solution containing 0.1% hydrochloric acid in step 1 as the percolation extraction solvent, the insufficient part is filled), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0082] (3) Use filter paper to suction filter the first concentrated solu...

Embodiment 3

[0088] Embodiment 3 belladonna extract

[0089] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0090] (1) Coarsely crush 1000 g of belladonna into a coarse powder (with a particle size of about 2.0 mm), add the coarse powder to an ethanol solution containing 0.3% hydrochloric acid (percolation extraction solvent), and ultrasonically mix at 600 W for 4 hours;

[0091] (2) The belladonna coarse powder after the ultrasonic treatment is carried out percolation (with the ethanol solution containing 0.3% hydrochloric acid in step 1 as the percolation extraction solvent, the insufficient part is made up), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0092] (3) Use filter paper to suction filter t...

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Abstract

The present invention relates to the technical field of medicine, in particular to a belladonna extract and a compound preparation of belladonna capsules; the extraction method of the belladonna extract comprises: percolating and extracting belladonna coarse powder with a solvent containing ethanol; the obtained The percolation extract is concentrated and washed with ethanol, and centrifuged to obtain a supernatant; the solvent contains 0.1-0.3% acid; the method also includes adjusting the pH value of the supernatant to 3-4, and using Macroporous resin (such as NKA-II type) is used for purification, and then gradient elution is performed with 80-95% and 65-75% ethanol solutions respectively. The extraction method of the invention can effectively reduce the content of chlorophyll and impurities in the belladonna extract and improve the quality of the belladonna extract. At the same time, the invention also provides a belladonna capsule compound preparation containing the belladonna extract, which can effectively improve the stability of the preparation by optimizing the components in the preparation and the preparation process.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound preparation of belladonna extract and belladonna capsules. Background technique [0002] The main source of belladonna extract is the extract made from processed belladonna herb. It is mainly used for gastric and duodenal ulcers, chronic gastritis, etc. [0003] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: take 1000 grams of belladonna coarse powder, use 85% ethanol as a solvent, and soak it for 48 hours at a rate of 1 to 3 ml per minute. Slowly percolate, collect about 3000ml of the initial decant liquid, store it in another device, continue percolation, and when the alkaloids are completely decanted, the continuous percolation liquid is used as the solvent for the next percolation; the initial decant liquid is decompressed at 60°C to recover ethanol , let cool to room temperature, separate th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/81A61K47/36A61K47/04A61P1/04A61P1/00A61K33/00
CPCA61K36/81A61K33/00A61K9/4866A61P1/00A61P1/04A61K9/485A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor 李泽恩常永亮黄元进王超毕英南张慧慧
Owner HONGMEI PHARMA CHINA
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