A kind of antibacterial nano material and its preparation method and application
A technology of nanomaterials and gold nanoparticles, which is applied in the field of aminophenol-modified gold nanoparticles and its preparation, can solve the problems of unclear antibacterial targets and mechanisms, not easy to circulate and metabolize, and complicated preparation methods, and achieve a wide range of clinical applications. Application prospect, excellent biocompatibility, high biosafety effect
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Embodiment 1
[0073] The present embodiment provides an antibacterial nanomaterial, the antibacterial nanomaterial is gold nanoparticles (2AP_Au NPs) modified by o-aminophenol, and its specific preparation steps are as follows:
[0074] (1) In a round bottom flask, 0.05 mmol of chloroauric acid trihydrate and 0.05 mmol of o-aminophenol (2AP, molecular weight 109.13) were added to 10 mL of deionized water. Then 50 μL of triethylamine and 30 mg of Tween 80 were added, and mixed in an ice-water bath for 10 min until the molecules were completely dissolved.
[0075] (2) Dissolve 6 mg of sodium borohydride in 2 mL of deionized water, and add it dropwise to a round bottom flask under vigorous stirring at 1000 r / min. The color of the solution in the bottle immediately changes from colorless to brown. Keep this reaction condition for another reaction 2h.
[0076] (3) The obtained gold nanoparticles reduced by anthranilic acid were dialyzed for 24 h with a dialysis bag to remove untreated chemical ...
Embodiment 2
[0079] The present embodiment provides an antibacterial nanomaterial, the antibacterial nanomaterial is gold nanoparticles (3AP_Au NPs) modified by m-aminophenol, and its specific preparation steps are as follows:
[0080] (1) In a round bottom flask, add 0.05 mmol of chloroauric acid trihydrate and 0.05 mmol of m-aminophenol (3AP, molecular weight 109.13) into 10 mL of deionized water. Then 50 μL of triethylamine and 30 mg of Tween 80 were added, and mixed in an ice-water bath for 10 min until the molecules were completely dissolved.
[0081] Steps (2) and (3) are the same as the steps for preparing o-aminophenol-modified gold nanoparticles in Example 1.
[0082] The morphology of 3AP_Au NPs was characterized by transmission electron microscopy, and the observation results are shown in Figure 3(a) and Figure 3(b). Among them, Fig. 3 (a) is the morphological characterization diagram of gold nanoparticles when the scale is 50nm, and Fig. 3 (b) is the morphological characteriza...
Embodiment 3
[0084] The present embodiment provides an antibacterial nanomaterial, the antibacterial nanomaterial is gold nanoparticles (4AP_Au NPs) modified by p-aminophenol, and its specific preparation steps are as follows:
[0085] (1) In a round bottom flask, add 0.05 mmol of chloroauric acid trihydrate and 0.05 mmol of p-aminophenol (4AP, molecular weight 109.13) into 10 mL of deionized water. Then 50 μL of triethylamine and 30 mg of Tween 80 were added, and mixed in an ice-water bath for 10 min until the molecules were completely dissolved.
[0086] Steps (2) and (3) are the same as the steps for preparing o-aminophenol-modified gold nanoparticles in Example 1.
[0087] The morphology of 4AP_Au NPs was characterized by transmission electron microscopy, and the observation results are shown in Figure 4(a) and Figure 4(b). Wherein, Fig. 4(a) is a morphological characterization diagram of gold nanoparticles when the scale is 50nm, and Fig. 4(b) is a morphological characterization diag...
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