Clinical application of doxycycline hydrochloride dispersible tablets as drug for treating demodicidosis skin lesion

A technology for doxycycline hydrochloride and demodicosis, applied in the field of medicine, can solve the problems of inability to prevent demodicosis, inflammatory granuloma, poor patient compliance, long medication cycle, etc., so as to relieve physical and mental pain and subside facial features. Skin lesions, the effect of simple treatment methods

Inactive Publication Date: 2020-09-04
罗洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used drugs include oral ivermectin, which can directly kill facial Demodex mites by using its antibacterial effect, but cannot prevent the formation of demodicosis inflammatory granulomas, and can cause neurotoxicity in large doses; , sulfur ointment, and 5% tea tree oil, but external drugs often have a long medication cycle, complicated usage, poor curative effect, and poor patient compliance; in addition, there are also systematic use of steroid drugs (betamethasone), etc.
Although there are many drugs for the treatment of demodicosis, there are still some deficiencies in their application

Method used

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  • Clinical application of doxycycline hydrochloride dispersible tablets as drug for treating demodicidosis skin lesion
  • Clinical application of doxycycline hydrochloride dispersible tablets as drug for treating demodicidosis skin lesion
  • Clinical application of doxycycline hydrochloride dispersible tablets as drug for treating demodicidosis skin lesion

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Embodiment Construction

[0047] Below, the present invention is example in conjunction with accompanying drawing with typical case, illustrates the curative effect of doxycycline hydrochloride dispersible tablet as the medicine for the treatment of demodicosis patient's skin lesion:

[0048] Typical case 1: Mr. Ma, male, 16 years old, suffered from "facial erythema papular nodular cyst for 1 year" in July 2018 ( Figure 4a ) in the dermatology clinic of our hospital, and the patient felt that his face was accompanied by mild itching. Demodex mites were observed under a microscope in the patient's skin lesions and hair follicle secretions, and the diagnosis was "demodex mangiosis". Advise the patient to take doxycycline hydrochloride dispersible tablet orally once a day during treatment, each 50mg. The 8th week of treatment ( Figure 4b ), the color of the erythema at the patient's facial skin lesions became lighter, the local papules calmed down compared with before, the nodules formed by inflammato...

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Abstract

The invention relates to clinical application of doxycycline hydrochloride dispersible tablets as a drug for treatment demodicosis skin lesion. A patient orally takes 50mg of the doxycycline hydrochloride dispersible tablets once a day, and one course of treatment lasts for 4 weeks. The clinical trials prove that the doxycycline hydrochloride dispersible tablets can obviously relieve the symptomsof erythema, papule, nodule, cyst and the like on the face of a patient suffering from the demodicosis, and can obviously inhibit leukocyte chemotaxis and granuloma formation in the demodicosis skin lesion. The doxycycline hydrochloride dispersible tablets are good in curative effect, high in safety, simple in treatment method, wide in applicable crowd, easier to accept by patients and suitable for popularization.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of doxycycline hydrochloride dispersible tablets, in particular to the clinical application of doxycycline hydrochloride dispersible tablets as a medicine for treating demodicosis skin lesions. [0002] technical background [0003] Doxycycline hydrochloride dispersible tablets (produced by Fuxiang (Dalian) Pharmaceutical Co., Ltd.) are broad-spectrum antibacterial agents, and have antibacterial effects at high concentrations. At present, doxycycline hydrochloride dispersible tablets are mainly used in the following diseases: (1) rickettsial diseases, such as epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever; (2) Mycoplasma infection; (3) Chlamydia infection, including psittacosis, venereal disease, lymphedema, non-specific urethritis, salpingitis, cervicitis and trachoma; (4) relapsing fever; (5) brucellosis; ( 6) cholera; (7) tularemia; (8) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/20A61P33/14A61P17/00A61P31/04
CPCA61K31/65A61K9/0053A61K9/20A61P17/00A61P33/14A61P31/04
Inventor 罗洋张剑虹吴岚曦周楠雒雪栾秀丽
Owner 罗洋
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