Hydrogel with excellent antibacterial performance for burn wound healing and preparation method of hydrogel

A wound healing and hydrogel technology, applied in bandages, medical science, etc., can solve the problems of not being able to reach hydrogel, unable to resist bacterial invasion, and not having antibacterial properties, and achieve excellent biocompatibility, good self-resistance, etc. The effect of repair performance, good postoperative cleaning convenience

Inactive Publication Date: 2020-09-11
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, after the hydrogel is placed on the wound, the movement of body muscles can easily lead to damage or even rupture of the colloid, which increases the risk of infection, and also destroys the structure of the hydrogel and affects its function.
In addition, the hydrogel itself is not antibacterial and cannot resist the invasion of bacteria, so there is a risk of infection
After long-term use of hydrogel, the hydrogel swells due to its strong water absorption

Method used

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  • Hydrogel with excellent antibacterial performance for burn wound healing and preparation method of hydrogel
  • Hydrogel with excellent antibacterial performance for burn wound healing and preparation method of hydrogel
  • Hydrogel with excellent antibacterial performance for burn wound healing and preparation method of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A hydrogel dressing for burn wound healing with excellent antibacterial properties, which is an ABA type triblock network copolymer polymerized from polyethylene glycol monomers and N-isopropylacrylamide monomers, the copolymer Comprising a mussel biomimetic tissue bonding group and a nanoparticle anchoring group, the hydrogel is loaded with silver nanoparticles and zinc nanoparticles, and cyclosporin A is loaded on the surface and inside of the hydrogel. Wherein the ABA type triblock network copolymer structural formula is as follows:

[0033]

[0034] The above-mentioned hydrogels have thermosensitive properties (such as figure 1 ), which is in a liquid state at room temperature or below body temperature, and turns into a gel state at body temperature or when it contacts the body surface, which is convenient for its storage and transportation, and is beneficial for surgical use such as spraying or injection.

[0035] The preparation method of the hydrogel refers t...

experiment example 1

[0042] Construct rat severe burn model, the hydrogel material obtained in embodiment 1 (with the mass ratio of polyethylene glycol monomer and N-isopropylacrylamide monomer 2:3, the number average molecular weight of polyethylene glycol is 10000 as an example) is used for repairing after burns, and the hydrogel material obtained in Example 1 is discussed for the protection of the local tissue recovery of rats after burns and the inhibition of systemic inflammatory response, the method is as follows:

[0043] Take 40 rats and divide them into 4 groups, control group (Control), model group (Burn), positive control group (Burn+Intrasite Gel), and experimental group (Burn+HydrogelA). All rats were shaved on the back, and carried out general anesthesia with 1% pentobarbital sodium 1mL intraperitoneal injection, taking the area as 30% of the total surface area (TBSA=K*W*0.5, K=0.9, W is the weight of the mouse) as burn area. All rats except the control group were anesthetized and s...

experiment example 2

[0049] The hydrogel prepared in "ACS applied materials&interfaces.2017; 9(11):9221-9225" was used in the above-mentioned severe burn model of rats, which was recorded as the positive control group 2. By loading CsA, it was compared with the experimental group of the present invention. The results are shown in Table 2:

[0050] Table 2

[0051]

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PUM

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Abstract

The invention provides hydrogel with excellent antibacterial performance for burn wound healing and a preparation method of the hydrogel. The hydrogel is an ABA type triblock reticular copolymer formed by polymerizing a polyethylene glycol monomer and an N-isopropylacrylamide monomer, wherein the copolymer comprises a mussel bionic tissue bonding group and a nanoparticle anchoring group; the hydrogel is loaded with silver nanoparticles and zinc nanoparticles, and cyclosporine A is carried on the surface and the interior of the hydrogel. The hydrogel material prepared by the invention has the characteristics of high strain, biocompatibility, adhesiveness, heat sensitivity, injectability, microbial resistance and the like, and can promote the healing speed of full-thickness burn wounds. Meanwhile, the antibacterial activity is excellent.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a hydrogel for healing burn wounds with excellent antibacterial properties and a preparation method thereof. Background technique [0002] Burn is a kind of tissue damage caused by various heat sources including hot liquid, high-temperature gas, flame, red-hot metal, chemical substances, etc., and mainly occurs in surface tissues such as skin and mucous membranes. After severe burns, in addition to regional local skin and mucous membrane damage, the following reactions may also occur: increased metabolism, decreased body temperature, excessive water loss, massive loss of protein, and disorders of the endocrine and immune systems. The exposed burn wounds, in addition to causing the body's fluid balance disorder and the destruction of the defense barrier in a short period of time, the wounds that do not heal for a long time will also become a breeding ground ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0004A61L26/0066A61L26/008A61L26/0061A61L2300/102A61L2300/104A61L2300/252A61L2300/404C08L87/005
Inventor 古君何谦毕思伟
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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