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A kind of medical suture and its preparation method and application

A suture and drug technology, applied in the field of medicine, can solve the problems of poor tissue compatibility, non-self-degradable medical suture, low strength, etc., and achieves simple preparation method, improved wound healing effect, and enhanced antibacterial effect.

Active Publication Date: 2022-01-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of medical suture and its preparation method and application in order to overcome the problems of medical suture which cannot be degraded autonomously in the body, poor tissue compatibility and low strength in the prior art

Method used

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  • A kind of medical suture and its preparation method and application
  • A kind of medical suture and its preparation method and application
  • A kind of medical suture and its preparation method and application

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preparation example Construction

[0027] The first aspect of the present invention provides a kind of preparation method of medical suture, this method comprises the following steps:

[0028] (1) Dissolve Zr salt and organic ligand in acetic acid according to the molar ratio of Zr ion to organic ligand (0.5-2):1, and mix and react at 110-130°C for 2-4h, and then cool in turn , washing, centrifuging and drying to obtain a Zr-based metal-organic framework material;

[0029] (2) adding the Zr-based metal-organic framework material obtained in step (1) into an organic solvent in which the drug is dissolved, and mixing at 50-70° C. for 2-4 days to obtain a drug-loaded metal-organic framework material;

[0030] (3) The drug-loaded metal-organic framework material obtained in step (2) is uniformly mixed with sodium alginate, then placed in a mold and fixed in a calcium chloride solution.

[0031] In the method of the present invention, in a specific embodiment, in step (1), the molar ratio of the Zr ion to the organ...

Embodiment 1

[0053] (1) ZrOCl 2 ·8H 2 O and pyridine 2,5-dicarboxylic acid are dissolved in acetic acid with a concentration of 45% by volume according to the molar ratio of Zr ion to pyridine 2,5-dicarboxylic acid as 1:1, and mixed and reacted at 120°C for 3h, then Cooling, washing, centrifugation and drying are carried out in sequence to obtain the Zr-based metal-organic framework material;

[0054] (2) Add the Zr-based metal-organic framework material obtained in step (1) into N,N-dimethylformamide dissolved in ibuprofen, wherein the Zr-based metal-organic framework material and the ibuprofen The mass ratio of the mixture is 1:10, mixed at 60°C for 3 days to obtain a metal-organic framework material loaded with ibuprofen;

[0055] (3) The metal-organic framework material loaded with ibuprofen obtained in step (2) is uniformly mixed with sodium alginate, and the mass ratio of the metal-organic framework material loaded with ibuprofen to the sodium alginate is 1: 7. Then place it in a ...

Embodiment 2

[0057] (1) ZrOCl 2 ·8H 2 O and terephthalic acid were dissolved in acetic acid with a concentration of 50% by volume according to the molar ratio of Zr ion to terephthalic acid of 2:1, and mixed and reacted at 130°C for 2h, followed by cooling, washing, centrifugation and Dry to obtain the Zr-based metal-organic framework material;

[0058] (2) Add the Zr-based metal-organic framework material obtained in step (1) into N,N-dimethylformamide dissolved with sodium ibuprofen, wherein the Zr-based metal-organic framework material and the ibuprofen The mass ratio of fen sodium is 1:15, mixed at 70°C for 2 days to obtain a metal-organic framework material loaded with ibuprofen sodium;

[0059] (3) The metal-organic framework material loaded with sodium ibuprofen obtained in step (2) is uniformly mixed with sodium alginate, and the mass ratio of the metal-organic framework material loaded with sodium ibuprofen to the sodium alginate is 1:8, then placed in a mold and fixed in a cal...

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Abstract

The invention relates to the field of medicine, in particular to a medical suture and its preparation method and application. The method comprises the following steps: (1) dissolving the Zr salt and the organic ligand according to the molar ratio of the Zr ion to the organic ligand being (0.5-2):1, and mixing and reacting at 110-130°C for 2-4h, and performing cooling, washing, centrifuging and drying to obtain a Zr-based metal-organic framework material; (2) adding a Zr-based metal-organic framework material to an organic solvent in which a drug is dissolved, and mixing at 50-70° C. for 2-4 days to obtain The material loaded with medicine; (3) uniformly mix the material loaded with medicine with sodium alginate, and then fix the mold in calcium chloride solution. The medical suture can omit the stitch removal step, simplify the treatment procedure, save medical resources, and reduce the burden on patients; it has drug loading and slow release properties, and can have the effects of antibacterial, wound treatment and infection prevention.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medical suture and its preparation method and application. Background technique [0002] With the diversification of diseases and the continuous development of medical technology, surgery occupies an important position in medical treatment, and suturing technology is one of the important factors for the success of surgery. A good medical suture is of great significance to the success rate of the operation. [0003] Traditional medical sutures cannot be degraded autonomously in the body and have poor tissue compatibility. They are usually used as foreign bodies and are prone to a series of incision complications such as rejection, inflammation, infection, and excessive scar hyperplasia. The incision pain and sinus formation High incidence. In the infected incision, the tension of the silk thread is obviously reduced, and the resulting wound infection often needs to be continuously take...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/06A61L17/00
CPCA61L17/10A61L17/06A61L17/005A61L2300/602A61L2300/41A61L2300/402A61L2300/404A61L2300/412C08L5/04
Inventor 林文鑫王岩黄霞娟余世桨贺庆高林辉祝洪良陈建军
Owner ZHEJIANG SCI-TECH UNIV
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