Pharmaceutical composition for resisting acinetobacter pathogenic bacteria

A technology of composition and pathogenic bacteria, which is applied in the direction of antibacterial drugs, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve the problems of invalidation of antibacterial drugs, inability to use, and difficulties in the treatment of aquatic animal diseases, and achieve good antibacterial activity without producing resistance. Medicinal properties, significant antibacterial effect

Active Publication Date: 2020-09-25
SHANGHAI OCEAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently effective antibiotics against Acinetobacter, except for doxycycline, which is an aquatic drug permitted by the Ministry of Agriculture and Rural Affairs, the rest are human and veterinary drugs and cannot be used in aquaculture
[0005] In addition, Acinetobacter pathogens also have multiple drug resistance, coupled with the impermeability of their outer wall structure, and carry a large number of drug resistance factors, they can quickly develop resistance to antibacterial drugs, resulting in the rapid failure of many antibacterial drugs. Treatment of aquatic animal diseases caused by
On the other hand, the extensive use of antimicrobials will also lead to the deterioration of the aquaculture ecological environment, resulting in drug residues and aquatic product quality and safety, which will further affect human health through the food chain

Method used

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  • Pharmaceutical composition for resisting acinetobacter pathogenic bacteria
  • Pharmaceutical composition for resisting acinetobacter pathogenic bacteria
  • Pharmaceutical composition for resisting acinetobacter pathogenic bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of the pharmaceutical composition against Acinetobacter pathogenic bacteria of Example 1

[0017] Weigh 200 mg of the Chinese herbal extracts of dihydromyricetin and honokiol respectively, add 1 L of sterile distilled water to dissolve, and obtain a dihydromyricetin solution with a concentration of 200 mg / L and a honokiol solution with a concentration of 200 mg / L (Chinese herbal medicine extraction). After mixing the two, the pharmaceutical composition with a total concentration of 400 mg / L was obtained; finally, it was sterilized by filtration through a microporous filter with a pore size of 0.22 μm, and stored at -20 °C for future use.

Embodiment 2

[0019] Preparation of the pharmaceutical composition against Acinetobacter pathogenic bacteria of Example 2

[0020] Weigh 100 mg of the Chinese herbal extracts of dihydromyricetin and honokiol respectively, add 1 L of sterile distilled water to dissolve, and obtain a dihydromyricetin solution with a concentration of 100 mg / L and a honokiol solution with a concentration of 100 mg / L (Chinese herbal medicine extraction). After mixing the two, the pharmaceutical composition with a total concentration of 200 mg / L was obtained; finally, it was filtered and sterilized through a 0.22 μm microporous filter, and stored at -20 °C for future use.

[0021] performance data

[0022] (1) Prove the effect of the pharmaceutical composition of the present application against Acinetobacter pathogenic bacteria

[0023] Acinetobacter venetianus strain SHF1, Acinetobacter lwwei strain R21, Acinetobacter lwudii strain BYK1451, Acinetobacter johnsonii strain BY3, Acinetobacter johnsonii strain BYK1...

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Abstract

The invention relates to a pharmaceutical composition for resisting acinetobacter pathogenic bacteria. The pharmaceutical composition comprises dihydromyricetin and magnolol, and the mass ratio of thedihydromyricetin to the magnolol is 1: 1. The pharmaceutical composition disclosed by the invention shows good antibacterial activity on an acinetobacter venetianus strain, an acinetobacter lwoffii strain, an acinetobacter johnsonii strain, an acinetobacter junii strain and an acinetobacter baumannii strain, and has broad-spectrum antibacterial property; more importantly, when the dihydromyricetin and the magnolol are compounded according to the specific mass ratio of 1: 1, the dihydromyricetin and the magnolol achieve a synergistic effect, the minimum inhibitory concentration is as low as 20mg / L, and the remarkable antibacterial effect is achieved; and moreover, the pharmaceutical composition belongs to a Chinese herbal medicine extract drug, is green and pollution-free, does not generate drug resistance, and can be widely applied to the field of aquaculture.

Description

technical field [0001] The invention relates to a pharmaceutical composition against Acinetobacter pathogenic bacteria, belonging to the technical field of aquatic antibacterial drugs. Background technique [0002] Acinetobacter is an emerging pathogen in aquaculture, which has caused morbidity and death of aquaculture animals such as sturgeon, bearded catfish, channel catfish, and bream, and caused a lot of economic losses. [0003] Common Acinetobacter species include Acinetobacter venezia, Acinetobacter lwoutii, Acinetobacter johnsonii, Acinetobacter agarinii, and Acinetobacter baumannii. [0004] Existing studies have shown that Acinetobacter is sensitive to a variety of antibiotics. For example, in the diagnosis and prevention of Acinetobacter infection in Schizothorax fry, doxycycline (40mg / Kg feed) mixed with feed + polyvitamin can be used. Ketone iodine (10%) for water splashing program. However, the antibiotics that are currently effective against Acinetobacter, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P31/04A61K31/05
CPCA61K31/05A61K31/353A61P31/04A61K2300/00
Inventor 安健曹海鹏陈百尧黄晓东张健顾颖
Owner SHANGHAI OCEAN UNIV
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