A kind of pharmaceutical composition for resisting Acinetobacter venezius pathogenic bacteria

A technology of composition and pathogenic bacteria, which is applied in the direction of antibacterial drugs, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as unusable, ineffective antibacterial drugs, and difficult treatment of aquatic animal diseases, so as to achieve no drug resistance and good Antibacterial activity, effect of remarkable antibacterial effect

Active Publication Date: 2021-06-18
SHANGHAI OCEAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently effective antibiotics against Acinetobacter, except for doxycycline, which is an aquatic drug permitted by the Ministry of Agriculture and Rural Affairs, the rest are human and veterinary drugs and cannot be used in aquaculture
[0005] In addition, Acinetobacter pathogens also have multiple drug resistance, coupled with the impermeability of their outer wall structure, and carry a large number of drug resistance factors, they can quickly develop resistance to antibacterial drugs, resulting in the rapid failure of many antibacterial drugs. Treatment of aquatic animal diseases caused by
On the other hand, the extensive use of antibacterial drugs will also cause the deterioration of the ecological environment of aquaculture, resulting in drug residues and the quality and safety of aquatic products, which will further affect human health through the food chain

Method used

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  • A kind of pharmaceutical composition for resisting Acinetobacter venezius pathogenic bacteria
  • A kind of pharmaceutical composition for resisting Acinetobacter venezius pathogenic bacteria
  • A kind of pharmaceutical composition for resisting Acinetobacter venezius pathogenic bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of the pharmaceutical composition of the antiacinetobacter pathogen of embodiment 1

[0017] Take respectively 200mg of the Chinese herbal medicine extract of dihydromyricetin and magnolol, after adding 1L of sterile distilled water to dissolve, obtain a concentration of 200mg / L dihydromyricetin solution and a concentration of 200mg / L magnolol solution (Chinese herbal medicine extract Mother liquor of the product), the two are mixed to obtain a pharmaceutical composition with a total concentration of 400mg / L; finally, the pore size is 0.22μm microporous filter for sterilization, and stored at -20°C for future use.

Embodiment 2

[0019] The preparation of the pharmaceutical composition of the antiacinetobacter pathogen of embodiment 2

[0020] Take respectively 100mg of the Chinese herbal medicine extract of dihydromyricetin and magnolol, add 1L of sterile distilled water to dissolve, and obtain a concentration of 100mg / L dihydromyricetin solution and a concentration of 100mg / L magnolol solution (Chinese herbal medicine extract Mother liquor of the product), the two are mixed to obtain a pharmaceutical composition with a total concentration of 200mg / L; finally, it is sterilized by filtering through a microporous filter with a pore size of 0.22 μm, and stored at -20°C for future use.

[0021] performance data

[0022] (1) Prove the effect of the anti-Acinetobacter pathogenic bacteria of the pharmaceutical composition of the present application

[0023] Acinetobacter venezii strain SHF1, Acinetobacter ruckeri strain R21, Acinetobacter ruckeri strain BYK1451, Acinetobacter johnsonii strain BY3, and Acine...

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Abstract

The present invention relates to a kind of pharmaceutical composition of anti-Acinetobacter pathogen, which comprises dihydromyricetin and magnolol, and the mass ratio of dihydromyricetin and magnolol is 1:1; Acinetobacter strains, Acinetobacter ruckeri strains, Acinetobacter johnsoni strains, Acinetobacter junii strains and Acinetobacter baumannii strains all exhibited good antibacterial activity with broad-spectrum antibacterial properties; more importantly, , when dihydromyricetin and magnolol are compounded with a specific mass ratio of 1:1, the two components are synergistic, and the minimum inhibitory concentration is as low as 20mg / L, which has a significant antibacterial effect; moreover The pharmaceutical composition of the present invention belongs to Chinese herbal medicine extracts, is green and pollution-free, does not produce drug resistance, and can be widely used in the field of aquaculture.

Description

technical field [0001] The invention relates to a pharmaceutical composition for resisting Acinetobacter venezii pathogenic bacteria, and belongs to the technical field of aquatic antibacterial drugs. Background technique [0002] Acinetobacter is an emerging pathogenic bacteria in aquaculture, which has caused the disease and death of aquaculture animals such as sturgeon, bearded catfish, channel catfish, and roundhead bream, causing a large amount of economic losses and hindering the targeted poverty alleviation work of the aquaculture industry to a certain extent proceed in an orderly manner. [0003] The common Acinetobacter species are Acinetobacter venezii, Acinetobacter ruckeri, Acinetobacter johnsonii, Acinetobacter johnsoni and Acinetobacter baumannii. [0004] Existing studies have shown that Acinetobacter is sensitive to a variety of antibiotics. For example, in the diagnosis and prevention of Acinetobacter infection in Schizothorax fry, doxycycline (40mg / Kg feed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P31/04A61K31/05
CPCA61K31/05A61K31/353A61P31/04A61K2300/00
Inventor 安健曹海鹏陈百尧黄晓东张健顾颖
Owner SHANGHAI OCEAN UNIV
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