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Toothpaste for children and preparation method thereof

A toothpaste and children's technology, which is applied in the medical field, can solve the problems of low foam volume, unguaranteed antibacterial effect, and ineffective prevention and treatment of dental caries, so as to reduce the quantity, ensure the safety of toothpaste matrix materials, and care for children's health Effect

Inactive Publication Date: 2020-09-25
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese patent with publication number CN108652999A provides a toothpaste for children. The toothpaste is safe, mild, non-irritating, moderate in friction, and the paste is transparent, smooth, delicate, and low in foam. It is suitable for children. However, the antibacterial properties of this toothpaste product The efficacy is not guaranteed, and children's oral problems, especially dental caries, cannot be effectively prevented and treated

Method used

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  • Toothpaste for children and preparation method thereof
  • Toothpaste for children and preparation method thereof
  • Toothpaste for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 oral antibacterial composition

[0027] This example provides a series of oral antibacterial compositions, which are formed by mixing the components shown in Table 1.

[0028] Table 1

[0029] formula Lysozyme (g) FOS (g) Rice Germ Extract (g) Recipe 1 0.5 1.5 3 Recipe 2 0.5 2 5 Recipe 3 1 1.5 3 Recipe 4 0.2 1.5 1 Recipe 5 0.2 1 1 Recipe 6 0.5 2 - Recipe 7 - 2 5 Recipe 8 0.5 - 5

Embodiment 2

[0030] Embodiment 2 Bacteriostatic activity experiment of antibacterial composition

[0031] 1. Antibacterial test method

[0032] According to 7.3 of QB 2738-2012 "Evaluation Method for Antibacterial and Antibacterial Effects of Daily Chemical Products" as the detection basis, to detect Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, Escherichia coli, Candida albicans, common The inhibition rate of bacteria etc. is an investigation index, and the bacteriostasis effect of 8 kinds of different bacteriostatic compositions in embodiment 1 is evaluated. The specific operation method is as follows:

[0033] (1) Dilute Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, Escherichia coli, Candida albicans, Prevotella intermedium and other bacteria with PBS (0.03mol / L phosphate buffer) solution to concentration 1×10 4 ~9×10 4 cfu / mL;

[0034] (2) Dilute the composition 1-8 test sample in Example 1 to a specified concentration with sterile...

Embodiment 3

[0048] The preparation of embodiment 3 children's toothpaste

[0049] 1. Raw materials

[0050] The ingredients of children's toothpaste with different ratios are shown in Table 3.

[0051] table 3

[0052]

[0053] 2. Preparation method of toothpaste

[0054] The one-step paste method is completed: after adding humectant, friction agent, adhesive, water, foaming agent, sweetener, fructooligosaccharide, and rice germ extract, keep the vacuum at -0.090Mpa~-0.096Mpa, and stir 20 to 50 minutes; then add essence and lysozyme, keep the vacuum at -0.090Mpa to -0.096Mpa, and stir for 10 to 50 minutes to prepare toothpaste 1 to 8.

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Abstract

The invention discloses toothpaste for children and a preparation method thereof. A compound of lysozyme, fructo-oligosaccharide and rice germ extract is added into the toothpaste, so that the quantity of oral pathogenic bacteria such as streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, escherichia coli, candida albicans and prevotella intermedia can be obviously reduced, andthe oral microenvironment is improved; meanwhile, the toothpaste has the remarkable proliferation promoting effect on intestinal beneficial bacteria such as bifidobacteria and lactic acid bacteria; and a toothpaste matrix is safe in material selection, so that even if the toothpaste is swallowed accidentally, no adverse effect is caused to the bodies of the children. The toothpaste solves the problems that toothpaste products containing chemical antibacterial components easily cause dysbiosis of oral bacteria, enable the bacteria to generate drug resistance and cannot achieve the effect of preventing oral diseases, is not added with chemical medicine components, does not contain fluorine, can better care the body health of the children, and enables the bodies of the children to develop healthily and well.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a toothpaste for children and a preparation method thereof. Background technique [0002] Oral health is an important part of overall health. Oral diseases such as caries and periodontal disease will destroy the hard tissues of the teeth and the supporting tissues around the teeth. In addition to affecting the functions of chewing, speech, and aesthetics, they will also cause social difficulties and psychological barriers According to the results of the "Fourth National Oral Health Epidemiological Survey", the caries prevalence rate of 5-year-old children in my country is as high as 70.9%, and that of 12-year-old children is as high as 34.5%. Among the oral diseases, 55.2% of primary and middle school students experienced oral diseases, and the rate of seeking medical treatment was only 26.4%, which fully shows that the current national oral health problems are very urgent. Youn...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61P1/02A61P31/02A61P31/04A61P31/10A61P1/00A61K8/9794A61K8/66A61K8/60A61Q11/00A61Q17/00A61K31/702A61K36/899
CPCA61K8/60A61K8/66A61K31/702A61K36/899A61K38/47A61K2800/592A61Q11/00A61Q17/005A61K8/9794A61P1/00A61P1/02A61P31/02A61P31/04A61P31/10C12Y302/01017A61K2300/00Y02A50/30
Inventor 耿帅峰褚夫江徐天生欧阳学琭李婷魏炜炜
Owner HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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