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Composition capable of increasing anoxia endurance, and preparation method thereof

A composition and tolerance technology, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of inconvenient taking, large toxic and side effects, etc., to save time, easy to obtain equipment, dry The effect of simple process

Inactive Publication Date: 2020-09-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many drugs and supplements to improve hypoxia tolerance, but these varieties have relatively toxic side effects and are inconvenient to take. People are looking for a product that is simple to make and easy to take to improve hypoxia tolerance.

Method used

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  • Composition capable of increasing anoxia endurance, and preparation method thereof
  • Composition capable of increasing anoxia endurance, and preparation method thereof
  • Composition capable of increasing anoxia endurance, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 A kind of orthogonal design for improving hypoxia tolerance composition

[0031] Get 4 weight parts of Radix Astragali, 4 weight parts of Lycium barbarum, 2 weight parts of American ginseng, 2 weight parts of Rhodiola rosea, water is extraction solvent, adopts L9 (3 4 ) orthogonal table to carry out orthogonal test, select water addition (8 times, 10 times, 12 times), extraction time (0.5h, 1.0h, 1.5h), extraction times (1 time, 2 times, 3 times) as 3 There are three factors to be investigated, and each factor has three levels. See the table below:

[0032] Table 1 Factor level table

[0033]

[0034] Table 2 Orthogonal experimental design

[0035]

[0036] The process evaluation indexes are total saponin content, crude polysaccharide content, salidroside content, and the determination of the content of three index components. The content of total saponins, crude polysaccharides, and salidroside in test numbers 1-9 were determined according to the...

Embodiment 2

[0047]Take 666.67g of Astragalus membranaceus, 666.67g of medlar, 333.33g of American ginseng, and 333.33g of Rhodiola rosea, add 12 times the amount of water to decoct and extract 3 times, each time for 1.5 hours, filter, combine the three extracts, and store them at 65±5℃ Concentrate under reduced pressure to a relative density of 1.20-1.30, dry under reduced pressure at 65±5°C to obtain a dry extract, crush the dry extract and pass through a 100-mesh sieve to obtain a dry extract powder. Weigh an appropriate amount of dry paste powder, add appropriate amount of auxiliary materials, mix evenly, add appropriate amount of 95% ethanol, stir to make a suitable soft material, granulate with a 16-mesh screen, dry at 60±5°C, control the moisture content of the particles at 4.0% to 6.0%, Sieve with a 16-mesh screen, add appropriate amount of auxiliary materials and mix evenly after sizing, compress into tablets after mixing evenly, and coat to make 1000 tablets.

Embodiment 3

[0049] Take 40kg of astragalus, 40kg of medlar, 20kg of American ginseng, and 20kg of rhodiola, add 10 times the amount of water to decoct and extract 3 times, each time for 1.0 hour, filter, combine the three extracts, and concentrate under reduced pressure at 65±5℃ , and concentrated to a relative density of 1.20 to 1.30, dried under reduced pressure at 65±5°C to obtain a dry extract, which was pulverized into a fine powder passing through a 100-mesh sieve with a universal pulverizer to obtain a dry paste powder.

[0050] Mixing: Weigh the dry paste powder and auxiliary materials according to the formula and put them into the wet mixing granulator, and mix for 5 minutes.

[0051] Making soft material: Add appropriate amount of 95% ethanol and stir to make suitable soft material.

[0052] Granulation: The prepared soft material is granulated with a 16-mesh sieve by a swinging granulator.

[0053] Drying: Dry the wet granules at 60±5°C, control the water content of the granul...

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Abstract

The invention provides a composition capable of increasing anoxia endurance, and a preparation method thereof. The traditional Chinese medicine composition mainly comprises 1-30 parts of radix astragali, 1-12 parts of fructus lycii, 1-6 parts of radix panacis quinquefolii and 1-6 parts of herba rhodiolae. the preparation method thereof comprises: (A) adding 8-14 times of amount of water into medicinal materials for decoction and extraction of 1-3 times, carrying out extraction for 0.5-2.0 h each time, carrying out filtration, combining extracting solutions and obtaining a filtrate; (B) carrying out reduced pressure concentration of the filtrate at the condition of 55-85 DEG C, concentrating the filtrate till the relative density reaches 1.10-1.30, carrying out reduced pressure drying at 55-85 DEG C to obtain a dry extract, and smashing and sieving the dry extract. An extraction technology of the composition provided by the invention is easy to operate, and the composition has a function of significantly increasing the anoxia endurance as proved in experiments.

Description

technical field [0001] The invention relates to the field of medicine, food or health products, in particular to a composition for improving hypoxia tolerance and a preparation method thereof. Background technique [0002] Oxygen is very important to maintain the life activities of the body. Hypoxia will first cause damage to the central nervous system, leading to cerebral edema and even irreversible necrosis of neurons; hypoxia will lead to reduced heart function, microcirculation disturbance, and eventually lead to insufficient blood supply to important organs throughout the body; Hypoxia can affect the oxidative respiration function of mitochondria, reduce the electron transfer rate of the respiratory chain and decouple oxidative phosphorylation, and ultimately affect the energy supply of the body; a large number of free radicals will be generated during hypoxia, resulting in serious damage to cell function; Oxygen can trigger apoptosis. [0003] At present, there are ma...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/30A61P39/00
CPCA61K9/282A61K36/258A61K36/41A61K36/481A61K36/815A61P39/00A61K2300/00
Inventor 肖伟张海弢付娟李曼曼范业文贾名强柏伟荣
Owner JIANGSU KANION PHARMA CO LTD
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