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A kind of preparation method and application of medicinal compound plant fatty acid zinc

A fatty acid zinc and plant technology, which is applied in the field of preparation of medicinal compound plant fatty acid zinc, to achieve the effect of easy-to-obtain raw materials, excellent performance and low price

Active Publication Date: 2021-02-19
BELIKE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a preparation method and application of medicinal compound plant fatty acid zinc to solve the problem of how to increase the zinc content of fatty acid zinc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] In an embodiment, the preparation method of the medicinal compound plant fatty acid zinc comprises the following steps:

[0028] S1: Pass nitrogen to the reaction kettle to exhaust oxygen, increase the nitrogen flow to 0.8-1.2L / min when exhausting oxygen, after the oxygen is exhausted, reduce the nitrogen flow to 0.1-0.2L / min, add 12- 18g of polyethylene glycol 200, 213-242g of linolenic acid, stirred and heated to 56-73°C at a rotation speed of 200-300r / min, to obtain a heated mixture A;

[0029] S2: Add 60-74g of zinc hydroxide powder to the mixture A prepared in step S1, and stir for 6-10min at a rotation speed of 300-400r / min to prepare a mixture B;

[0030] S3: Heat the mixture B prepared in step S2 to 110-116°C at a microwave power of 300-400W, add 22-25g of water and 10-15g of propionic anhydride, keep the microwave power and temperature constant, and increase the speed to 600 Stir the reaction at -800r / min for 25-35min to prepare the reactant;

[0031] S4: Fil...

Embodiment 1

[0034] A preparation method of medicinal compound plant fatty acid zinc, comprising the following steps:

[0035] S1: Vent nitrogen to the reactor to exhaust oxygen. Increase the nitrogen flow rate to 0.9L / min when exhausting oxygen. After exhausting oxygen, reduce the nitrogen flow rate to 0.1L / min, and add 12.2g polyethylene glycol under nitrogen protection. 200, 215g of linolenic acid, stirred and heated to 58°C at a rotation speed of 200r / min, to obtain a heated mixture A;

[0036] S2: Add 62g of zinc hydroxide powder to the mixture A prepared in step S1, and stir for 10min at a rotating speed of 300r / min to prepare a mixture B;

[0037] S3: Heat the mixture B prepared in step S2 to 112°C at a microwave power of 300W, add 22g of water and 12g of propionic anhydride, keep the microwave power and temperature constant, increase the rotation speed to 600r / min and stir for 34min to prepare get reactants;

[0038] S4: Filtering, dehydrating, and recovering propionic acid and p...

Embodiment 2

[0040] A preparation method of medicinal compound plant fatty acid zinc, comprising the following steps:

[0041] S1: Pass nitrogen to the reaction kettle to exhaust oxygen, increase the nitrogen flow to 1.2L / min when oxygen is exhausted, after the oxygen is exhausted, reduce the nitrogen flow to 0.1L / min, add 16g of polyethylene glycol 200 under the protection of nitrogen 1. 226g of linolenic acid was stirred and heated to 68°C at a rotation speed of 300r / min to obtain a heated mixture A;

[0042] S2: Add 68g of zinc hydroxide powder to the mixture A prepared in step S1, and stir for 6min at a rotation speed of 400r / min to prepare a mixture B;

[0043] S3: Heat the mixture B prepared in step S2 to 115°C at a microwave power of 400W, add 24g of water and 13g of propionic anhydride, keep the microwave power and temperature constant, increase the rotation speed to 800r / min and stir for 25min to prepare get reactants;

[0044] S4: Filtering, dehydrating, and recovering propioni...

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Abstract

The invention discloses a preparation method of medicinal composite plant fatty acid zinc, comprising the following steps of: S1: adding polyethylene glycol 200 and linolenic acid under the protectionof nitrogen, and heating while stirring to obtain a heated mixture A; S2, adding zinc hydroxide powder into the mixture A prepared in the step S1, and stirring to obtain a mixture B; S3, heating themixture B prepared in the step S2 under microwaves, adding water and propionic anhydride, keeping the microwave power and temperature unchanged, increasing the rotating speed, and stirring for reaction to obtain a reactant; and S4, filtering and dehydrating the reactant prepared in the step S3, recovering propionic acid and polyethylene glycol 200, and then introducing water for cooling while stirring to prepare the composite plant fatty acid zinc. The medicinal composite plant fatty acid zinc prepared by the invention can be used as a novel non-toxic, green and environment-friendly medicinalproduct, the zinc content is as high as 15.67% or above, the performance is excellent, and the application requirements in the field of medicines can be met.

Description

technical field [0001] The invention belongs to the technical field of fatty acid zinc preparation, and in particular relates to a preparation method and application of medicinal compound plant fatty acid zinc. Background technique [0002] The English name of fatty acid zinc (Zinc Fatty Acid) is called ZNFA for short. The industrial products are usually light yellow powder or white granules. It is widely used in medical and other fields. [0003] The Chinese patent application document "A Preparation Process for Fatty Acid Zinc by Melting Method (Application Publication No.: CN102344352A)" discloses a method for preparing fatty acid zinc by melting method. In the method, fatty acid, zinc oxide, and acetic acid are reacted at a temperature higher than the melting point of the fatty acid, nitrogen protection is carried out during the reaction, and nitrogen protection is carried out after the reaction for granulation or slicing to obtain granular or sheet-packed fatty acid zi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/41C07C57/12
CPCC07C51/412C07C57/12
Inventor 郭向荣王海
Owner BELIKE CHEM