Morphometric genotyping of cells using optical tomography for detecting tumor mutational burden
A technique of mutation load and metrology, which is applied in the fields of genomics, informatics, and analytical materials, and can solve the problems of unreliable detection of TMB
Pending Publication Date: 2020-10-02
VISIONGATE
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[0010] However, until the disclosure herein, there was no reliable method for detecting TMB using optical tomography
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[0024] The following disclosure describes methods for developing one or more morphometric classifiers to identify tumor mutational burden (TMB). Several features of methods and systems according to exemplary embodiments are illustrated and described in the drawings. It will be appreciated that methods and systems according to other exemplary embodiments may include additional procedures or features other than those shown in the figures. Exemplary embodiments are described herein with respect to an optical tomography cellular imaging system. It should be understood, however, that these examples are for illustrative purposes of principles and the invention is not limited thereto.
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A method to develop one or more morphometric classifiers to identify a tumor mutation burden (TMB). The method provides a non-invasive method of characterizing TMB that is responsive to a tumor in itsearly stages of development and irrespective of the tumor size. The method allows targeting cancer therapy to the specific characteristics of the cancer that the patient may have, allowing more efficient cancer management with far fewer side effects.
Description
technical field [0001] The present invention relates to optical tomography at the cellular and subcellular scales. More specifically, the present invention relates to a system and method for developing one or more morphometric classifiers to identify tumor mutational burden (TMB). Background technique [0002] Altered nuclear morphology has been a major histopathological biomarker for cancer detection for the past 140 years. A direct link between chromatin organization in the nucleus and cellular function at the level of DNA replication, translation, and protein expression has been demonstrated in many published studies 1-3 . In particular, the organization of chromatin, which underlies the 3D architecture of the nucleus, is thought to be a major factor affecting regional and global mutation rates in human cancer cells 4-5 . [0003] Current approaches to treating many types of cancer involve targeting immune system checkpoint inhibitors CTLA4, PD-1 and PD-L1, proteins i...
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Login to View More IPC IPC(8): G16B40/20C12Q1/6886
CPCC12Q1/6886C12Q2600/106C12Q2600/156G16B40/20G16B20/00G16B20/50C12Q2525/301G01N2800/50
Inventor 丹尼尔·J·萨斯曼米歇尔·G·梅耶莱莫尼斯·科布卡斯阿兰·C·内尔松兰道·马斯特兰杰洛
Owner VISIONGATE