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Aza aromatic ring amide derivatives for use in treatment of cancer

A heterocyclic and heteroaryl technology, applied in the field of azaaromatic cyclic amides, can solve problems such as the lack of effective drugs targeting HER4

Pending Publication Date: 2020-10-09
SHENZHEN FORWARD PHARMA LTD CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still a lack of effective drugs targeting HER4 in clinical practice.

Method used

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  • Aza aromatic ring amide derivatives for use in treatment of cancer
  • Aza aromatic ring amide derivatives for use in treatment of cancer
  • Aza aromatic ring amide derivatives for use in treatment of cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0272] According to the compound of formula (I) described in the first aspect of the present invention, its chemical synthesis and preparation can refer to articles published by Zeng, QB, etc. in Journal of Medicinal Chemistry, 2015, 58, 8200-8215, and patent WO2018 / 210246 (A1 ), CN105461695A, CN201410365911A, CN201610126987A, CN109761960 and CN106928200A, which are selected from the following compounds:

[0273] N-(2-((2-(dimethylamino)ethyl(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl )-1,3,5-triazin-2-yl)amino)phenyl)acrylamide (compound 1);

[0274]

[0275] N-(5-((4-(3,3-Dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-1,3,5-tri (oxazin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide (compound 2);

[0276]

[0277] N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(3-methyl-1H-pyrrolo[3, 2-c]pyridin-1-yl)-1,3,5-triazin-2-yl)amino)phenyl)acrylamide (compound 3);

[0278]

[0279] N-(2-((2-(dimethylamino)e...

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Abstract

The present invention relates to pyrimidine derivatives for the treatment of cancer. Specifically, the present invention relates to anilino-pyrimidine compounds of Formula (I), Formula (II), Formula (III) and Formula (IV) and pharmaceutically acceptable salts thereof; wherein the compound or the salts thereof can be used for the treatment or prevention of diseases or disorders by modulating certain mutated forms of epidermal growth factor receptors. The present invention also relates to pharmaceutical compositions comprising said compounds or salts thereof, and methods of using said compoundsand salts thereof in the treatment of a variety of diseases mediated by EGFR, HER2 and / or HER4 in the ErbB family.

Description

technical field [0001] The invention provides a pyrimidine derivative capable of regulating the activity of ErbB family kinases. Specifically, the present invention relates to the use of azaaromatic cyclic amides. The present invention relates to azaaromatic amide compounds and pharmaceutically acceptable salts thereof, which are useful for treating or preventing diseases or conditions by modulating certain mutant forms of epidermal growth factor receptors. The present invention also relates to pharmaceutical compositions comprising said compounds or salts thereof, and methods of using said compounds and salts thereof to treat various diseases mediated by various forms of EGFR or HER2 or HER4, including non-small cell Lung cancer, etc. Background technique [0002] In the field of anticancer drugs, there is a constant need for new anticancer compounds with better activity / selectivity. EGFR, HER2, and HER4 are known to be members of the transmembrane protein tyrosine kinas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/04C07D471/04C07D401/14C07D487/04C07D495/04C07D239/48C07D403/12A61P35/00A61P35/02A61K31/53A61K31/506A61K31/5377A61K31/519A61K31/517A61K31/55
CPCC07D471/04C07D403/04A61P35/00A61P35/02C07D401/14C07D487/04C07D495/04C07D239/48C07D403/12A61K31/506A61K31/517A61K31/53A61K31/55C07D251/16A61K45/06A61K2300/00A61K31/519
Inventor 朱程刚杨铉张朝春陈超乐包丽茗徐良亮郭玉函
Owner SHENZHEN FORWARD PHARMA LTD CO