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tsRNA marker for detecting cancer tissue and para-carcinoma tissue of pancreatic cancer, probe and application thereof

A technology for paracancerous tissue and pancreatic cancer, applied in the field of tsRNA markers and probes, can solve problems such as differential treatment effects, and achieve the effects of improving sensitivity and specificity, easy detection, and stable expression

Pending Publication Date: 2020-10-16
王延博
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  • Abstract
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  • Application Information

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Problems solved by technology

At present, one of the most commonly used pathological indicators in tumor treatment is the tumor stage, but a large number of clinical data show that tumor patients in the same stage still have significant differences in the therapeutic effect of the same treatment.

Method used

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  • tsRNA marker for detecting cancer tissue and para-carcinoma tissue of pancreatic cancer, probe and application thereof
  • tsRNA marker for detecting cancer tissue and para-carcinoma tissue of pancreatic cancer, probe and application thereof
  • tsRNA marker for detecting cancer tissue and para-carcinoma tissue of pancreatic cancer, probe and application thereof

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Embodiment

[0027] A tsRNA marker for detecting cancer tissue and paracancerous tissue of pancreatic cancer, the tsRNA marker is any one or a combination of the following sequences:

[0028] tRF-Pro-AGG-004: SEQ ID No. 1;

[0029] tRF-Leu-CAG-002: SEQ ID No. 2.

[0030] The present invention provides an in situ hybridization probe, which detects the above-mentioned tsRNA markers used in the detection of pancreatic cancer tissue and paracancerous tissue; sequence SEQ ID No.3 and / or SEQ ID No.4. The in situ hybridization probes are 3' and 5' labeled locked nucleic acid (LNA) oligonucleotide probes from Exiqon.

[0031] The present invention provides the application of the above-mentioned tsRNA marker and in situ hybridization probe in the preparation of a pancreatic cancer diagnostic kit.

[0032] The present invention provides a kit for diagnosis and prognosis of pancreatic cancer, which is used to detect tRF-Pro-AGG-004 and / or tRF-Leu-CAG-004 in pancreatic cancer tissue and adjacent ti...

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Abstract

The invention belongs to the technical field of biology, and discloses a tsRNA marker for detecting cancer tissue and para-carcinoma tissue of pancreatic cancer, and application thereof in prognosis and survival judgment of pancreatic cancer. The tsRNA marker is tRF-Pro-AGG-004 and / or tRF-Leu-CAG-002. The marker can be used for preparing a kit for monitoring and prognosis evaluation of pancreaticcancer.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a tsRNA marker, a probe and an application thereof for detecting cancer tissue and paracancerous tissue of pancreatic cancer. Background technique [0002] Pancreatic cancer is one of the deadliest types of malignant tumors, its 5-year survival rate is only about 5%, and the median survival period is less than half a year. Therefore, for pancreatic cancer patients, it is particularly important to be able to quickly and quickly judge the prognosis after a certain treatment in order to select the best treatment plan. At present, one of the most commonly used pathological indicators in tumor treatment is tumor staging, but a large number of clinical data show that tumor patients in the same stage still have significant differences in the therapeutic effect of the same treatment. Therefore, screening sensitive and effective biomarkers and assessing the prognosis of patients with pancreati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6841C12N15/113
CPCC12Q1/6886C12Q1/6841C12Q2600/158C12Q2600/178C12Q2600/118
Inventor 王延博金芳芳
Owner 王延博
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