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Application of nicotinic acid derivatives in relieving female reproductive system aging injury

A reproductive system and derivative technology, applied in the fields of application, medical preparations containing active ingredients, diseases, etc., can solve the problems of pathological aging of the female reproductive system that have not yet been prevented, etc.

Inactive Publication Date: 2020-10-20
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, the female reproductive system is a complex multi-organ interaction system, so the problem can only be solved from the fundamental problem of cell aging, but as of the eve of the patent application, there is no safe and effective method to prevent and treat pathological changes in the female reproductive system by targeting cellular ROS damage. Proven Solution for Aging

Method used

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  • Application of nicotinic acid derivatives in relieving female reproductive system aging injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Evaluation of efficacy and safety based on high-throughput standardized cell experiments.

[0031] On the basis of previous work, high-throughput standard cell experiments were used to screen the dosage range of nicotinic acid-based derivatives such as nicotinamide, nicotinic acid, nicotinamide riboside and nicotinamide mononucleotide.

[0032] Based on the previous work of the present invention, on the basis of gradient treatment, the absorbance method was used to measure cell viability, ATP production, intracellular ROS level and β-galactosidase activity, and the average value was taken as the effect index on the basis of normalization of the above data , based on the data of 5 independent experiments, the T-test analysis was carried out; with P0.01 Dose as the toxicity dose threshold of the component. The data show that the effective range, optimal dose and toxicity threshold of several representative nicotinic acid-based derivatives are nicotinamide (10-50...

Embodiment 2

[0033] Example 2 Effect experiment on premature ovarian failure animal model mice.

[0034] Based on the optimal dose obtained in Example 1, the recovery of estrogen in mice was measured. Three independent experiments with 120 mice found that the pretreatment group was 21.6% higher than the negative control group, and the T test found that the difference was significant. The above data indicate that the nicotinic acid-based derivatives can effectively increase the estrogen level in premature ovarian failure animal model mice.

Embodiment 3

[0035] Example 3 A randomized double-blind controlled multi-center volunteer experiment of this formula at an optimal concentration.

[0036] From June 2018 to October 2019, in Beijing, Xi'an and Xianyang, a total of 150 female premature ovarian failure volunteers were selected, with an average age of 36.2 years and a body mass index of 21.9. Volunteers were externally applied niacin-based derivatives whose appearance could not be distinguished, and marketed products B and C for 120 days (formulation A was given the optimal dose according to Example 1, and products B and C were taken according to the instructions). Volunteer experiments were conducted on the principle of double-blind control.

[0037] Serum estrogen levels, menstrual status, and serum follicle-stimulating hormone levels of volunteers were measured, and the above results were normalized to generate a score for female reproductive system impairment. The results showed that formula A could finally reduce volunte...

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Abstract

Aging of a female reproductive system is a key problem of female aging, the core of the problem is cell aging, and reactive oxygen species metabolism disorder widely damages biomacromolecules and thelike and is a main molecular mechanism of cell pathological aging damage. Through long-term experimental screening and verification, the inventor finds that nicotinamide, nicotinic acid, nicotinamidemononucleotide and other nicotinic acid-based derivatives can improve the intracellular NADH and DNADP levels and correct reactive oxygen species metabolism disorders, thereby improving the disease-resistant rational oxidative damage capacity of female reproductive system cells. The inventor also finds that multiple nicotinic acid group derivatives only have difference in pharmacokinetics and other aspects and can be replaced with one another to a certain extent. On the basis, the invention discloses application of the nicotinic acid derivatives in the aspects of medicines, health care products or functional foods for relieving female reproductive system aging injury by comprehensively correcting reactive oxygen species metabolic disorders.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to the application of a medicament, a health care product or a functional food for comprehensively correcting metabolic disorders through niacin derivatives and alleviating aging damage of the female reproductive system. Background technique [0002] With the increasing aging of my country's population, health problems caused by aging have become a huge challenge. The aging of the female reproductive system not only causes fertility decline, but also endocrine disorders such as low estrogen and progesterone levels, which lead to the decline of multiple systems and organ functions throughout the body, and may also lead to decreased energy, memory loss, sleep disorders, depression, etc. Nervous system and mental and psychological symptoms are even closely related to the occurrence and development of major chronic diseases such as diabetes and cardiovascular and cerebrovascular diseases. The...

Claims

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Application Information

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IPC IPC(8): A61K31/455A61K31/706A23L33/10A61P39/06A61P15/08
CPCA61K31/455A61K31/706A23L33/10A61P39/06A61P15/08A23V2002/00A23V2200/302A23V2200/30
Inventor 贺鑫
Owner NORTHWEST A & F UNIV
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